Screening for preterm birth: Potential for a metabolomics biomarker panel

Considine, Elizabeth C.; Khashan, Ali S.; Kenny, Louise C.

Screening for preterm birth: Potential for a metabolomics biomarker panel

dc.contributor.author	Considine, Elizabeth C.
dc.contributor.author	Khashan, Ali S.
dc.contributor.author	Kenny, Louise C.
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-11-20T05:01:33Z
dc.date.available	2019-11-20T05:01:33Z
dc.date.issued	2019-05-07
dc.description.abstract	The aim of this preliminary study was to investigate the potential of maternal serum to provide metabolomic biomarker candidates for the prediction of spontaneous preterm birth (SPTB) in asymptomatic pregnant women at 15 and/or 20 weeks’ gestation. Metabolomics LC-MS datasets from serum samples at 15- and 20-weeks’ gestation from a cohort of approximately 50 cases (GA < 37 weeks) and 55 controls (GA > 41weeks) were analysed for candidate biomarkers predictive of SPTB. Lists of the top ranked candidate biomarkers from both multivariate and univariate analyses were produced. At the 20 weeks’ GA time-point these lists had high concordance with each other (85%). A subset of 4 of these features produce a biomarker panel that predicts SPTB with a partial Area Under the Curve (pAUC) of 12.2, a sensitivity of 87.8%, a specificity of 57.7% and a p-value of 0.0013 upon 10-fold cross validation using PanelomiX software. This biomarker panel contained mostly features from groups already associated in the literature with preterm birth and consisted of 4 features from the biological groups of “Bile Acids”, “Prostaglandins”, “Vitamin D and derivatives” and “Fatty Acids and Conjugates”.	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	90	en
dc.identifier.citation	Considine, E.C., Khashan, A.S. and Kenny, L.C., 2019. Screening for Preterm Birth: Potential for a Metabolomics Biomarker Panel. Metabolites, 9(5), 90. (19pp). doi:10.3390/metabo9050090	en
dc.identifier.doi	10.3390/metabo9050090	en
dc.identifier.eissn	2218-1989
dc.identifier.endpage	19
dc.identifier.issn	2218-1989
dc.identifier.issued	5	en
dc.identifier.journaltitle	Metabolites	en
dc.identifier.startpage	1
dc.identifier.uri	https://hdl.handle.net/10468/9106
dc.identifier.volume	9	en
dc.language.iso	en	en
dc.publisher	MDPI	en
dc.relation.uri	https://www.mdpi.com/2218-1989/9/5/90
dc.rights	© 2019 by the authors. Licensee MDPI, Basel, Switzerland	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Metabolomics	en
dc.subject	Prediction	en
dc.subject	Complex disease	en
dc.subject	Heterogeneity	en
dc.subject	Biomarkers	en
dc.subject	Panel	en
dc.subject	Preterm birth	en
dc.title	Screening for preterm birth: Potential for a metabolomics biomarker panel	en
dc.type	Article (peer-reviewed)	en