Screening for preterm birth: Potential for a metabolomics biomarker panel

dc.contributor.authorConsidine, Elizabeth C.
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorKenny, Louise C.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-11-20T05:01:33Z
dc.date.available2019-11-20T05:01:33Z
dc.date.issued2019-05-07
dc.description.abstractThe aim of this preliminary study was to investigate the potential of maternal serum to provide metabolomic biomarker candidates for the prediction of spontaneous preterm birth (SPTB) in asymptomatic pregnant women at 15 and/or 20 weeks’ gestation. Metabolomics LC-MS datasets from serum samples at 15- and 20-weeks’ gestation from a cohort of approximately 50 cases (GA < 37 weeks) and 55 controls (GA > 41weeks) were analysed for candidate biomarkers predictive of SPTB. Lists of the top ranked candidate biomarkers from both multivariate and univariate analyses were produced. At the 20 weeks’ GA time-point these lists had high concordance with each other (85%). A subset of 4 of these features produce a biomarker panel that predicts SPTB with a partial Area Under the Curve (pAUC) of 12.2, a sensitivity of 87.8%, a specificity of 57.7% and a p-value of 0.0013 upon 10-fold cross validation using PanelomiX software. This biomarker panel contained mostly features from groups already associated in the literature with preterm birth and consisted of 4 features from the biological groups of “Bile Acids”, “Prostaglandins”, “Vitamin D and derivatives” and “Fatty Acids and Conjugates”.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid90en
dc.identifier.citationConsidine, E.C., Khashan, A.S. and Kenny, L.C., 2019. Screening for Preterm Birth: Potential for a Metabolomics Biomarker Panel. Metabolites, 9(5), 90. (19pp). doi:10.3390/metabo9050090en
dc.identifier.doi10.3390/metabo9050090en
dc.identifier.eissn2218-1989
dc.identifier.endpage19
dc.identifier.issn2218-1989
dc.identifier.issued5en
dc.identifier.journaltitleMetabolitesen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/9106
dc.identifier.volume9en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttps://www.mdpi.com/2218-1989/9/5/90
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerlanden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMetabolomicsen
dc.subjectPredictionen
dc.subjectComplex diseaseen
dc.subjectHeterogeneityen
dc.subjectBiomarkersen
dc.subjectPanelen
dc.subjectPreterm birthen
dc.titleScreening for preterm birth: Potential for a metabolomics biomarker panelen
dc.typeArticle (peer-reviewed)en
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