dc.check.date	2021-05-21
dc.check.info	Access to this article is restricted until 12 months after publication by request of the publisher.	en
dc.contributor.author	McElwain, Colm
dc.contributor.author	McCarthy, Cathal M.
dc.contributor.funder	Health Research Board	en
dc.date.accessioned	2020-08-04T09:45:04Z
dc.date.available	2020-08-04T09:45:04Z
dc.date.issued	2020-05-21
dc.date.updated	2020-08-04T09:37:02Z
dc.description.abstract	Objective: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance which is diagnosed during pregnancy and poses considerable health risks for mother and child. Maternal body mass index (BMI) correlates with GDM diagnosis and the pathophysiology of this link may be explained through oxidative stress and mitochondrial dysfunction. In this study we investigate if mitochondrial dysfunction is evident in GDM by measuring cell free mitochondrial DNA concentration and determine if a potential relationship exists between maternal mitochondrial function and GDM diagnosis. Study design: Plasma samples were taken at 20 weeks' gestation from women who subsequently developed GDM (n = 44) and matched with women with uncomplicated pregnancies (n = 85) as controls. Control group 1 was matched by maternal age and BMI (n = 41) to GDM cases, while control group 2 was matched by maternal age alone (n = 44). Prediction potential was determined by binary regression analysis. Statistical analysis was performed on SPSS Statistics v25. Results: Binary regression analysis showed a statistically significant association between mtDNA concentration and GDM diagnosis (p = 0.032) in GDM cases versus control group 2, indicating that GDM patients have higher circulating mtDNA concentrations relative to healthy control patients. The lack of statistical significance in control group 1 suggests that BMI may be linked to mitochondrial function in GDM patients. Conclusion: These results demonstrate a potential pathogenic role for mitochondrial dysfunction in GDM, with BMI presenting as a likely physiological mediator.	en
dc.description.sponsorship	Health Research Board (Project Code: HRB-EIA-2017-021)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	McElwain, C. and McCarthy, C. M. (2020) 'Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator', European Journal of Obstetrics and Gynecology and Reproductive Biology, 251, pp. 60-65. doi: 10.1016/j.ejogrb.2020.04.037	en
dc.identifier.doi	10.1016/j.ejogrb.2020.04.037	en
dc.identifier.endpage	65	en
dc.identifier.issn	0301-2115
dc.identifier.journaltitle	European Journal of Obstetrics and Gynecology and Reproductive Biology	en
dc.identifier.startpage	60	en
dc.identifier.uri	https://hdl.handle.net/10468/10351
dc.identifier.volume	251	en
dc.language.iso	en	en
dc.publisher	Elsevier B.V.	en
dc.rights	© 2020, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Adiposity	en
dc.subject	GDM	en
dc.subject	Insulin resistance	en
dc.subject	Mitochondria	en
dc.title	Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator	en
dc.type	Article (peer-reviewed)	en

Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator

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