dc.contributor.author	Gomez, Andres
dc.contributor.author	Sharma, Ashok Kumar
dc.contributor.author	Mallott, Elizabeth K.
dc.contributor.author	Petrzelkova, Klara J.
dc.contributor.author	Jost Robinson, Carolyn A.
dc.contributor.author	Yeoman, Carl J.
dc.contributor.author	Carbonero, Franck
dc.contributor.author	Pafco, Barbora
dc.contributor.author	Rothman, Jessica M.
dc.contributor.author	Ulanov, Alexander
dc.contributor.author	Vlckova, Klara
dc.contributor.author	Amato, Katherine R.
dc.contributor.author	Schnorr, Stephanie L.
dc.contributor.author	Dominy, Nathaniel J.
dc.contributor.author	Modry, David
dc.contributor.author	Todd, Angelique
dc.contributor.author	Torralba, Manolito
dc.contributor.author	Nelson, Karen E.
dc.contributor.author	Burns, Michael B.
dc.contributor.author	Blekhman, Ran
dc.contributor.author	Remis, Melissa
dc.contributor.author	Stumpf, Rebecca M.
dc.contributor.author	Wilson, Brenda A.
dc.contributor.author	Gaskins, H. Rex
dc.contributor.author	Garber, Paul A.
dc.contributor.author	White, Bryan A.
dc.contributor.author	Leigh, Steven R.
dc.contributor.funder	European Social Fund	en
dc.contributor.funder	National Science Foundation	en
dc.contributor.funder	Czech-American Scientific cooperation	en
dc.contributor.funder	Ministry of Education, Youth and Sports of The Czech Republic	en
dc.date.accessioned	2019-10-14T22:17:36Z
dc.date.available	2019-10-14T22:17:36Z
dc.date.issued	2019-07-31
dc.description.abstract	The gut microbiome of primates, including humans, is reported to closely follow host evolutionary history, with gut microbiome composition being specific to the genetic background of its primate host. However, the comparative models used to date have mainly included a limited set of closely related primates. To further understand the forces that shape the primate gut microbiome, with reference to human populations, we expanded the comparative analysis of variation among gut microbiome compositions and their primate hosts, including 9 different primate species and 4 human groups characterized by a diverse set of subsistence patterns (n = 448 samples). The results show that the taxonomic composition of the human gut microbiome, at the genus level, exhibits increased compositional plasticity. Specifically, we show unexpected similarities between African Old World monkeys that rely on eclectic foraging and human populations engaging in nonindustrial subsistence patterns; these similarities transcend host phylogenetic constraints. Thus, instead of following evolutionary trends that would make their microbiomes more similar to that of conspecifics or more phylogenetically similar apes, gut microbiome composition in humans from nonindustrial populations resembles that of generalist cercopithecine monkeys. We also document that wild cercopithecine monkeys with eclectic diets and humans following nonindustrial subsistence patterns harbor high gut microbiome diversity that is not only higher than that seen in humans engaging in industrialized lifestyles but also higher compared to wild primates that typically consume fiber-rich diets. IMPORTANCE: The results of this study indicate a discordance between gut microbiome composition and evolutionary history in primates, calling into question previous notions about host genetic control of the primate gut microbiome. Microbiome similarities between humans consuming nonindustrialized diets and monkeys characterized by subsisting on eclectic, omnivorous diets also raise questions about the ecological and nutritional drivers shaping the human gut microbiome. Moreover, a more detailed understanding of the factors associated with gut microbiome plasticity in primates offers a framework to understand why humans following industrialized lifestyles have deviated from states thought to reflect human evolutionary history. The results also provide perspectives for developing therapeutic dietary manipulations that can reset configurations of the gut microbiome to potentially improve human health.	en
dc.description.sponsorship	Czech Republic (project OPVK CZ.1.07/2.3.00/20.0300); Czech-American Scientific cooperation (Project number LH15175)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	e00271-19	en
dc.identifier.citation	Gomez, A., Sharma, A. K., Mallott, E. K., Petrzelkova, K. J., Jost Robinson, C. A., Yeoman, C. J., Carbonero, F., Pafco, B., Rothman, J. M., Ulanov, A., Vlckova, K., Amato, K. R., Schnorr, S. L., Dominy, N. J., Modry, D., Todd, A., Torralba, M., Nelson, K. E., Burns, M. B., Blekhman, R., Remis, M., Stumpf, R. M., Wilson, B. A., Gaskins, H. R., Garber, P. A., White, B. A. and Leigh, S. R. (2019) 'Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints', mSphere, 4(4), e00271-19 (14pp.) DOI: 10.1128/mSphere.00271-19	en
dc.identifier.doi	10.1128/mSphere.00271-19	en
dc.identifier.eissn	2379-5042
dc.identifier.endpage	14	en
dc.identifier.issued	4	en
dc.identifier.journaltitle	mSphere	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/8764
dc.identifier.volume	4	en
dc.language.iso	en	en
dc.publisher	American Society for Microbiology	en
dc.relation.project	info:eu-repo/grantAgreement/NSF/Directorate for Social, Behavioral & Economic Sciences::Division of Behavioral and Cognitive Sciences/0935347/US/Microbes, Diet, and Hominin Evolution: Comparative and Metagenomic Approaches/	en
dc.relation.uri	https://msphere.asm.org/content/4/4/e00271-19
dc.rights	©2019 Gomez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	Evolution	en
dc.subject	Microbiome	en
dc.subject	Primate	en
dc.title	Plasticity in the human gut microbiome defies evolutionary constraints	en
dc.type	Article (peer-reviewed)	en

Plasticity in the human gut microbiome defies evolutionary constraints

Files

Original bundle

License bundle

Collections