Relationships between maternal obesity and maternal and neonatal iron status

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dc.contributor.authorFlynn, Angela C.
dc.contributor.authorBegum, Shahina
dc.contributor.authorWhite, Sara
dc.contributor.authorDalrymple, Kathryn
dc.contributor.authorGill, Carolyn
dc.contributor.authorAlwan, Nisreen
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorLatunde-Dada, Gladys
dc.contributor.authorBell, Ruth
dc.contributor.authorBriley, Annette
dc.contributor.authorNelson, Scott
dc.contributor.authorOteng-Ntim, Eugene
dc.contributor.authorSandall, Jane
dc.contributor.authorSanders, Thomas
dc.contributor.authorWhitworth, Melissa
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorPoston, Lucilla
dc.contributor.authorSCOPE UPBEAT Consortiums
dc.contributor.funderCanterbury Medical Research Foundation
dc.contributor.funderHealth Research Board
dc.contributor.funderNational Institute for Health Research
dc.contributor.funderAllen Foundation
dc.date.accessioned2018-09-27T12:08:23Z
dc.date.available2018-09-27T12:08:23Z
dc.date.issued2018
dc.description.abstractObesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese (n = 245, BMI ≥ 30 kg/m2) and normal weight (n = 245, BMI < 25 kg/m2) age matched pregnant women collected at approximately 15 weeks’ gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C- reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs. 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs. 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women (P < 0.001). Women from ethnic minority groups (n = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.en
dc.description.sponsorshipNational Institute for Health Research (NIHR RP-0407-10452); Health Research Board (CSA/2007/2; http://www.hrb.ie); Canterbury Medical Research Foundation (National Children’s Research Centre)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1000
dc.identifier.citationFlynn, A., Begum, S., White, S., Dalrymple, K., Gill, C., Alwan, N., Kiely, M., Latunde-Dada, G., Bell, R., Briley, A., Nelson, S., Oteng-Ntim, E., Sandall, J., Sanders, T., Whitworth, M., Murray, D., Kenny, L., Poston, L., and On behalf of the SCOPE and UPBEAT Consortiums (2018) 'Relationships between Maternal Obesity and Maternal and Neonatal Iron Status', Nutrients, 10(8), 1000 (10pp). doi: 10.3390/nu10081000en
dc.identifier.doi10.3390/nu10081000
dc.identifier.endpage10
dc.identifier.issn2072-6643
dc.identifier.issued8
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6942
dc.identifier.volume10
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttp://www.mdpi.com/2072-6643/10/8/1000
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPregnancyen
dc.subjectObesityen
dc.subjectInflammationen
dc.subjectIron statusen
dc.titleRelationships between maternal obesity and maternal and neonatal iron statusen
dc.typeArticle (peer-reviewed)en
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