Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits

dc.contributor.authorBrennan, Ann-Marie
dc.contributor.authorKiely, Mairead E.
dc.contributor.authorFenton, Sarah
dc.contributor.authorMurphy, Brendan
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2018-03-09T12:55:07Z
dc.date.available2018-03-09T12:55:07Z
dc.date.issued2018
dc.description.abstractThe optimal composition of standardized parenteral nutrition (SPN) is not yet known, contributing to nutrient deficit accrual and growth failure, with the period of parenteral nutrition weaning, i.e., transition (TN) phase, being identified as particularly vulnerable. We created a comprehensive nutrition database, representative of the nutritional course of a diverse range of preterm infants (n = 59, birth weight ≤ 1500 g, gestation < 34 weeks) by collecting hourly macronutrient intake data as part of a prospective, observational study over 19 months. Using a nutrient modeling technique for the TN phase, various amino acid (AA) concentrations of SPN were tested within the database, whilst acknowledging the nutritional contribution from enteral feeds until target AA intakes were consistently achieved. From the modeling, the AA composition of SPN was determined at 3.5 g/100 mL, which was the maximum to avoid exceeding target intakes at any point in the TN phase. However, in order to consistently achieve target AA intakes, additional nutritional strategies were required, which included increasing the exclusion of enteral feeds in fluid and nutrient calculations from <20 mL/kg/day to <40 mL/kg/day, and earlier fortification of breastmilk at 80 mL/kg/day. This data-driven nutrient modeling process supported the development of an improved SPN regimen for our preterm population in the TN phase.en
dc.description.sponsorshipScience Foundation Ireland (PINPOINT project (Personalised nutrition for the preterm infant; 13SP INFANT B2888)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid170
dc.identifier.citationBrennan, A.-M., Kiely, M., Fenton, S. and Murphy, B. (2018) 'Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits', Nutrients, 10(2), 170 (11pp). doi: 10.3390/nu10020170en
dc.identifier.doi10.3390/nu10020170
dc.identifier.endpage11
dc.identifier.issn2072-6643
dc.identifier.issued1
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5611
dc.identifier.volume10
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme/13/SP INFANT/B2888/IE/Personalise Nutrition for the Preterm Infant (PiNPoiNT)/
dc.relation.urihttp://www.mdpi.com/2072-6643/10/2/170
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectStandardized parenteral nutritionen
dc.subjectTransition phaseen
dc.subjectNutrient modelingen
dc.subjectAmino acidsen
dc.subjectEnteral nutritionen
dc.subjectPreterm infantsen
dc.titleStandardized parenteral nutrition for the transition phase in preterm infants: a bag that fitsen
dc.typeArticle (peer-reviewed)en
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