Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits
dc.contributor.author | Brennan, Ann-Marie | |
dc.contributor.author | Kiely, Mairead E. | |
dc.contributor.author | Fenton, Sarah | |
dc.contributor.author | Murphy, Brendan | |
dc.contributor.funder | Science Foundation Ireland | |
dc.date.accessioned | 2018-03-09T12:55:07Z | |
dc.date.available | 2018-03-09T12:55:07Z | |
dc.date.issued | 2018 | |
dc.description.abstract | The optimal composition of standardized parenteral nutrition (SPN) is not yet known, contributing to nutrient deficit accrual and growth failure, with the period of parenteral nutrition weaning, i.e., transition (TN) phase, being identified as particularly vulnerable. We created a comprehensive nutrition database, representative of the nutritional course of a diverse range of preterm infants (n = 59, birth weight ≤ 1500 g, gestation < 34 weeks) by collecting hourly macronutrient intake data as part of a prospective, observational study over 19 months. Using a nutrient modeling technique for the TN phase, various amino acid (AA) concentrations of SPN were tested within the database, whilst acknowledging the nutritional contribution from enteral feeds until target AA intakes were consistently achieved. From the modeling, the AA composition of SPN was determined at 3.5 g/100 mL, which was the maximum to avoid exceeding target intakes at any point in the TN phase. However, in order to consistently achieve target AA intakes, additional nutritional strategies were required, which included increasing the exclusion of enteral feeds in fluid and nutrient calculations from <20 mL/kg/day to <40 mL/kg/day, and earlier fortification of breastmilk at 80 mL/kg/day. This data-driven nutrient modeling process supported the development of an improved SPN regimen for our preterm population in the TN phase. | en |
dc.description.sponsorship | Science Foundation Ireland (PINPOINT project (Personalised nutrition for the preterm infant; 13SP INFANT B2888) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | 170 | |
dc.identifier.citation | Brennan, A.-M., Kiely, M., Fenton, S. and Murphy, B. (2018) 'Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits', Nutrients, 10(2), 170 (11pp). doi: 10.3390/nu10020170 | en |
dc.identifier.doi | 10.3390/nu10020170 | |
dc.identifier.endpage | 11 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.issued | 1 | |
dc.identifier.journaltitle | Nutrients | en |
dc.identifier.startpage | 1 | |
dc.identifier.uri | https://hdl.handle.net/10468/5611 | |
dc.identifier.volume | 10 | |
dc.language.iso | en | en |
dc.publisher | MDPI AG | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Spokes Programme/13/SP INFANT/B2888/IE/Personalise Nutrition for the Preterm Infant (PiNPoiNT)/ | |
dc.relation.uri | http://www.mdpi.com/2072-6643/10/2/170 | |
dc.rights | © 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Standardized parenteral nutrition | en |
dc.subject | Transition phase | en |
dc.subject | Nutrient modeling | en |
dc.subject | Amino acids | en |
dc.subject | Enteral nutrition | en |
dc.subject | Preterm infants | en |
dc.title | Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits | en |
dc.type | Article (peer-reviewed) | en |