A prospective metagenomic and metabolomic analysis of the impact of exercise and/or whey protein supplementation on the gut microbiome of sedentary adults

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dc.contributor.authorCronin, Owen
dc.contributor.authorBarton, Wiley
dc.contributor.authorSkuse, Peter
dc.contributor.authorPenney, Nicholas C.
dc.contributor.authorGarcia-Perez, Isabel
dc.contributor.authorMurphy, Eileen F.
dc.contributor.authorWoods, Trevor
dc.contributor.authorNugent, Helena
dc.contributor.authorFanning, Aine
dc.contributor.authorMelgar, Silvia
dc.contributor.authorFalvey, Éanna
dc.contributor.authorHolmes, Elaine
dc.contributor.authorCotter, Paul D.
dc.contributor.authorO'Sullivan, Orla
dc.contributor.authorMolloy, Michael G.
dc.contributor.authorShanahan, Fergus
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderDiabetes Research & Wellness Foundation
dc.contributor.funderNational Institute for Health Research
dc.contributor.funderIrish Centre for Arthritis Research and Education
dc.date.accessioned2018-05-31T11:56:29Z
dc.date.available2018-05-31T11:56:29Z
dc.description.abstractMany components of modern living exert influence on the resident intestinal microbiota of humans with resultant impact on host health. For example, exercise-associated changes in the diversity, composition, and functional profiles of microbial populations in the gut have been described in cross-sectional studies of habitual athletes. However, this relationship is also affected by changes in diet, such as changes in dietary and supplementary protein consumption, that coincide with exercise. To determine whether increasing physical activity and/or increased protein intake modulates gut microbial composition and function, we prospectively challenged healthy but sedentary adults with a short-term exercise regime, with and without concurrent daily whey protein consumption. Metagenomics- and metabolomics-based assessments demonstrated modest changes in gut microbial composition and function following increases in physical activity. Significant changes in the diversity of the gut virome were evident in participants receiving daily whey protein supplementation. Results indicate that improved body composition with exercise is not dependent on major changes in the diversity of microbial populations in the gut. The diverse microbial characteristics previously observed in long-term habitual athletes may be a later response to exercise and fitness improvement.en
dc.description.sponsorshipDiabetes Research & Wellness Foundation (Sutherland-Earl Clinical Research Fellowship 2015); National Institute for Health Research (Imperial-Clinical Phenome Centre; Biomedical Research Centre)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00044-18
dc.identifier.citationCronin, O., Barton, W., Skuse, P., Penney, N. C., Garcia-Perez, I., Murphy, E. F., Woods, T., Nugent, H., Fanning, A., Melgar, S., Falvey, E. C., Holmes, E., Cotter, P. D., O’Sullivan, O., Molloy, M. G. and Shanahan, F. (2018) 'A prospective metagenomic and metabolomic analysis of the impact of exercise and/or whey protein supplementation on the gut microbiome of sedentary adults', mSystems, 3(3), e00044-18 (17pp). doi: 10.1128/mSystems.00044-18en
dc.identifier.doi10.1128/mSystems.00044-18
dc.identifier.endpage17
dc.identifier.issn2379-5077
dc.identifier.issued2018
dc.identifier.journaltitlemSystemsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6227
dc.identifier.volume3
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/11/PI/1137/IE/Obesibiotics/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2160/IE/Investigating the impact of high intensity exercise and/or protein intake levels on gut microbial diversity./
dc.relation.urihttp://msystems.asm.org/content/3/3/e00044-18
dc.rights© 2018, Cronin et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International license.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBacteriophagesen
dc.subjectExerciseen
dc.subjectMetabolismen
dc.subjectMicrobial communitiesen
dc.subjectNext-generation sequencingen
dc.subjectWhey proteinen
dc.titleA prospective metagenomic and metabolomic analysis of the impact of exercise and/or whey protein supplementation on the gut microbiome of sedentary adultsen
dc.typeArticle (peer-reviewed)en
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