A multifunctional platform for the production and customization of polymer-based microneedle devices

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dc.contributor.authorBocchino, Andreaen
dc.contributor.authorMárquez-Graña, C.en
dc.contributor.authorSingh, Om Prakashen
dc.contributor.authorMelnik, Evaen
dc.contributor.authorKurzhals, Steffenen
dc.contributor.authorMutinati, Giorgio C.en
dc.contributor.authorCoulman, S. A.en
dc.contributor.authorMartin, Christopheren
dc.contributor.authorNg, Keng Wooien
dc.contributor.authorMassufero Vergilio, Marianeen
dc.contributor.authorBirchall, J. C.en
dc.contributor.authorDonovan, P.en
dc.contributor.authorGalvin, Paulen
dc.contributor.authorO'Mahony, Conoren
dc.contributor.funderHorizon 2020en
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderResearch Irelanden
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.date.accessioned2025-10-17T13:14:54Z
dc.date.available2025-10-17T13:14:54Z
dc.date.issued2025-03-21en
dc.description.abstractPolymer microneedles (MNs) have significant potential for use in transdermal delivery and diagnostics applications due to their low cost, versatility, and compatibility with medical grade materials and industrial manufacturing processes. These polymers can also have a wide range of different and desirable properties such as biocompatibility, degradability, and flexibility. To facilitate rapid development of these devices, a multifunctional manufacturing process, easily adaptable to a range of different materials and use cases, would be highly beneficial for research and prototyping purposes. With that in mind, we have developed a multifunctional platform that may be used to produce sharp-tipped microneedle arrays with a variety of substrate materials, mechanical characteristics, electrical properties, and diagnostic functionalities. The paper first presents an outline of the platform concept and the double-sided moulding process that lies at its core, followed by a description of the various add-on steps that are used to customise the geometrical, mechanical, electrical, and functional aspects of the arrays. Finally, we illustrate the versatility of the platform with three exemplars, namely a solid, electrochemically active MN sensor for biomarker diagnostics, a fabric-backed, flexible MN electrode for biopotential monitoring, and a biodegradable array for transdermal drug delivery.en
dc.description.sponsorshipGovernment of Ireland (Disruptive Technologies Innovation Fund (DT2018 0291-A, HOLISTICS)); Enterprise Ireland (Commercialisation Fund (CF/2012/2339))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid116491en
dc.identifier.citationBocchino, A., Marquez-Grana, C., Singh, O.P., Melnik, E., Kurzhals, S., Mutinati, G.C., Coulman, S., Martin, C., Ng, K.W., Massufero Vergilio, M., Birchall, J., Donovan, P., Galvin, P. and O’Mahony, C. (2025) 'A multifunctional platform for the production and customization of polymer-based microneedle devices', Sensors and Actuators A: Physical, 388, 116491 (14pp). https://doi.org/10.1016/j.sna.2025.116491en
dc.identifier.doi10.1016/j.sna.2025.116491en
dc.identifier.eissn1873-3069en
dc.identifier.endpage14en
dc.identifier.issn0924-4247en
dc.identifier.journaltitleSensors and Actuators A: Physicalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/18064
dc.identifier.volume388en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/825549/EU/Electronic smart patch system for wireless monitoring of molecular biomarkers for healthcare and well-being/ELSAHen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/Research Centres Programme::Phase 2/12/RC/2289_P2/IE/INSIGHT_Phase 2 /en
dc.rights© 2025, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectMicroneedlesen
dc.subjectMouldingen
dc.subjectPolymeren
dc.subjectTransdermal drug deliveryen
dc.subjectECG electrodeen
dc.subjectSensorsen
dc.subjectMedical devicesen
dc.titleA multifunctional platform for the production and customization of polymer-based microneedle devicesen
dc.typeArticle (peer-reviewed)en
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