Psychotropics and the microbiome: A chamber of secrets…

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dc.contributor.authorCussotto, Sofia
dc.contributor.authorClarke, Gerard
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderMead Johnson Nutritionen
dc.contributor.funderCremoen
dc.contributor.funderDuPonten
dc.contributor.funderSuntory Wellnessen
dc.contributor.funderDanone-Nutriciaen
dc.contributor.funder4D Pharmaen
dc.date.accessioned2019-11-23T06:39:25Z
dc.date.available2019-11-23T06:39:25Z
dc.date.issued2019-05
dc.description.abstractThe human gut contains trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. Psychotropic medications act on the central nervous system (CNS) and are used in the treatment of various psychiatric disorders. There is increasing emphasis on the bidirectional interaction between drugs and the gut microbiome. An expanding body of evidence supports the notion that microbes can metabolise drugs and vice versa drugs can modify the gut microbiota composition. In this review, we will first give a comprehensive introduction about this bidirectional interaction, then we will take into consideration different classes of psychotropics including antipsychotics, antidepressants, antianxiety drugs, anticonvulsants/mood stabilisers, opioid analgesics, drugs of abuse, alcohol, nicotine and xanthines. The varying effects of these widely used medications on microorganisms are becoming apparent from in vivo and in vitro studies. This has important implications for the future of psychopharmacology pipelines that will routinely need to consider the host microbiome during drug discovery and development.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCussotto, S., Clarke, G., Dinan, T.G. and Cryan, J.F. (2019) 'Psychotropics and the Microbiome: a Chamber of Secrets…' Psychopharmacology, 236(5), pp.1411–1432. doi: 10.1007/s00213-019-5185-8en
dc.identifier.doi10.1007/s00213-019-5185-8en
dc.identifier.eissn1432-2072
dc.identifier.endpage1432en
dc.identifier.issn0033-3158
dc.identifier.issued5en
dc.identifier.journaltitlePsychopharmacologyen
dc.identifier.startpage1411en
dc.identifier.urihttps://hdl.handle.net/10468/9193
dc.identifier.volume236en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00213-019-5185-8
dc.rights© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPsychotropicen
dc.subjectAntipsychoticen
dc.subjectAntidepressanten
dc.subjectAntimicrobialen
dc.subjectGut microbiomeen
dc.titlePsychotropics and the microbiome: A chamber of secrets…en
dc.typeArticle (peer-reviewed)en
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