Is matrix Gla protein associated with vascular calcification? A systematic review

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dc.contributor.authorBarrett, Hilary
dc.contributor.authorO'Keeffe, Mary
dc.contributor.authorKavanagh, Eamon
dc.contributor.authorWalsh, Michael
dc.contributor.authorO'Connor, Eibhlís M.
dc.contributor.funderIrish Research Council
dc.contributor.funderEuropean Regional Development Fund
dc.contributor.funderIrish Heart Foundation
dc.date.accessioned2018-05-02T10:16:29Z
dc.date.available2018-05-02T10:16:29Z
dc.date.issued2018
dc.description.abstractSpecific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla protein (MGP), a tissue-derived vitamin K dependent protein, is reported to be an important inhibitor of vascular calcification and may have clinical potential to modify the progression of vascular calcification through regulation of functional MGP fractions. This systematic review examines twenty-eight studies which assess the relationship between circulating protein expressions of MGP species and vascular calcification in different arterial beds. The included studies examined participants with atherosclerosis, chronic kidney disease (CKD), diabetes, healthy participants, vitamin K supplementation, measured plasma vitamin K levels and vitamin K antagonist usage. The current review reports conflicting results regarding MGP fractions with respect to local calcification development indicating that a multifaceted relationship exists between the MGP and calcification. A primary concern regarding the studies in this review is the large degree of variability in the calcification location assessed and the fraction of MGP measured. This review suggests that different underlying molecular mechanisms can accelerate local disease progression within the vasculature, and specific circulating fractions of MGP may be influenced differently depending on the local disease states related to vascular calcification development. Further studies examining the influence of non-functional MGP levels, with respect to specific calcified arterial beds, are warranted.en
dc.description.sponsorshipIrish Research Council (GOIPG/2013/1309; New Foundations); European Regional Development Fund(Irish Government’s Programme for Research in Third Level Institutions Ref. 1102357)/Irish Heart Foundation (Stroke Prevention Research)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid415
dc.identifier.citationBarrett, H., O’Keeffe, M., Kavanagh, E., Walsh, M. and O’Connor, E. (2018) 'Is matrix Gla protein associated with vascular calcification? A systematic review', Nutrients, 10(4), 415 (18pp). doi: 10.3390/nu10040415en
dc.identifier.doi10.3390/nu10040415
dc.identifier.endpage18
dc.identifier.issn2072-6643
dc.identifier.issued4
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5963
dc.identifier.volume10
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.urihttp://www.mdpi.com/2072-6643/10/4/415
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMatrix-Gla-proteinen
dc.subjectVascular calcificationen
dc.subjectVitamin Ken
dc.subjectCardiovascular diseaseen
dc.subjectAtherosclerosisen
dc.subjectChronic kidney diseaseen
dc.subjectDiabetesen
dc.subjectHealthy participantsen
dc.titleIs matrix Gla protein associated with vascular calcification? A systematic reviewen
dc.typeArticle (peer-reviewed)en
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