Roles of the gut virome and mycobiome in faecal microbiota transplantation

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dc.contributor.authorLam, Siu
dc.contributor.authorBai, Xiaowu
dc.contributor.authorShkoporov, Andrey N.
dc.contributor.authorPark, Heekuk
dc.contributor.authorWu, Xiaojian
dc.contributor.authorLan, Ping
dc.contributor.authorZuo, Tao
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderSun Yat-sen Universityen
dc.contributor.funderGuangdong Gastrointestinal Hospital, Chinaen
dc.contributor.funderWellcome Trusten
dc.date.accessioned2022-04-19T09:36:54Z
dc.date.available2022-04-19T09:36:54Z
dc.date.issued2022-04-06
dc.date.updated2022-04-19T09:03:30Z
dc.description.abstractFaecal microbiota transplantation (FMT) is an innovative approach to treat diseases that are associated with gut dysbiosis, by transferring a healthy stool microbiota to a recipient with disease. Beyond the bacteriome, the human gut also harbours diverse communities of viruses and fungi, collectively known as the virome and the mycobiome. The effect of the virome and the mycobiome on the success of FMT therapy has not been appreciated until recently. In this Review, we summarise the current literature on the effects of the gut virome and mycobiome on the treatment of various diseases with FMT. We discuss the beneficial effects and health concerns of viral and fungal transfer during FMT, and highlight the roles of bacteriophages and Candida species in FMT efficacy. We also summarise the intricate relationships between the gut virome, mycobiome, bacteriome, and host immunity underlying FMT effectiveness. Future efforts should be devoted to understanding the versatile roles and the therapeutic mechanisms of viral and fungal lineages, and their combinations, in different diseases. Harnessing the gut virome, mycobiome, and bacteriome in combination is a promising prospect for the future of FMT and microbiota-based therapies.en
dc.description.sponsorshipWellcome Trust (Research Career Development Fellowship 220646/Z/20/Z)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLam, S., Bai, X., Shkoporov, A. N., Park, H., Wu, X., Lan, P. and Zuo, T. (2022) 'Roles of the gut virome and mycobiome in faecal microbiota transplantation', The Lancet Gastroenterology & Hepatology, 7(5), pp. 472-484. doi: 10.1016/S2468-1253(21)00303-4en
dc.identifier.doi10.1016/S2468-1253(21)00303-4en
dc.identifier.eissn2468-1253
dc.identifier.endpage484en
dc.identifier.issued5en
dc.identifier.journaltitleThe Lancet Gastroenterology & Hepatologyen
dc.identifier.startpage472en
dc.identifier.urihttps://hdl.handle.net/10468/13096
dc.identifier.volume7en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.rights© 2021, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectFaecal microbiota transplantation (FMT)en
dc.subjectBacteriomeen
dc.subjectViromeen
dc.subjectMycobiomeen
dc.subjectWellcome Trusten
dc.titleRoles of the gut virome and mycobiome in faecal microbiota transplantationen
dc.typeArticle (peer-reviewed)en
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