Gutsy moves: the amygdala as a critical node in microbiota to brain signaling
dc.contributor.author | Cowan, Caitlin S. M. | |
dc.contributor.author | Hoban, Alan E. | |
dc.contributor.author | Ventura-Silva, Ana Paula | |
dc.contributor.author | Dinan, Timothy G. | |
dc.contributor.author | Clarke, Gerard | |
dc.contributor.author | Cryan, John F. | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | Horizon 2020 | en |
dc.contributor.funder | European Commission | en |
dc.date.accessioned | 2017-12-04T16:26:08Z | |
dc.date.available | 2017-12-04T16:26:08Z | |
dc.date.issued | 2017-11-17 | |
dc.date.updated | 2017-12-04T15:59:02Z | |
dc.description.abstract | The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. | en |
dc.description.sponsorship | Science Foundation Ireland (“HEALTHMARK”by Science Foundation Ireland (SFI), Ireland (16/ERA-HDHL/3362)) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Cowan, C. S. M., Hoban, A. E., Ventura-Silva, A. P., Dinan, T. G., Clarke, G. and Cryan, J. F. 'Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling', BioEssays, 1700172 (12pp), In Press. doi:10.1002/bies.201700172 | en |
dc.identifier.doi | 10.1002/bies.201700172 | |
dc.identifier.endpage | 1700172-12 | en |
dc.identifier.issn | 1521-1878 | |
dc.identifier.journaltitle | Bioessays | en |
dc.identifier.startpage | 1700172-1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/5116 | |
dc.language.iso | en | en |
dc.publisher | Wiley | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
dc.relation.project | info:eu-repo/grantAgreement/EC/H2020::CSA/696300/EU/The second coordination and support action for the JPI Healthy Diet for a Healthy Life/CSA JPI HDHL 2.0 | en |
dc.rights | © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Anxiety | en |
dc.subject | Fear | en |
dc.subject | Gut-brain axis | en |
dc.subject | Limbic system | en |
dc.subject | Pain | en |
dc.subject | Social behavior | en |
dc.subject | Stress | en |
dc.title | Gutsy moves: the amygdala as a critical node in microbiota to brain signaling | en |
dc.type | Article (peer-reviewed) | en |