Gutsy moves: the amygdala as a critical node in microbiota to brain signaling

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dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorHoban, Alan E.
dc.contributor.authorVentura-Silva, Ana Paula
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorClarke, Gerard
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHorizon 2020en
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2017-12-04T16:26:08Z
dc.date.available2017-12-04T16:26:08Z
dc.date.issued2017-11-17
dc.date.updated2017-12-04T15:59:02Z
dc.description.abstractThe amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond.en
dc.description.sponsorshipScience Foundation Ireland (“HEALTHMARK”by Science Foundation Ireland (SFI), Ireland (16/ERA-HDHL/3362))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCowan, C. S. M., Hoban, A. E., Ventura-Silva, A. P., Dinan, T. G., Clarke, G. and Cryan, J. F. 'Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling', BioEssays, 1700172 (12pp), In Press. doi:10.1002/bies.201700172en
dc.identifier.doi10.1002/bies.201700172
dc.identifier.endpage1700172-12en
dc.identifier.issn1521-1878
dc.identifier.journaltitleBioessaysen
dc.identifier.startpage1700172-1en
dc.identifier.urihttps://hdl.handle.net/10468/5116
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::CSA/696300/EU/The second coordination and support action for the JPI Healthy Diet for a Healthy Life/CSA JPI HDHL 2.0en
dc.rights© 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAnxietyen
dc.subjectFearen
dc.subjectGut-brain axisen
dc.subjectLimbic systemen
dc.subjectPainen
dc.subjectSocial behavioren
dc.subjectStressen
dc.titleGutsy moves: the amygdala as a critical node in microbiota to brain signalingen
dc.typeArticle (peer-reviewed)en
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