Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

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dc.contributor.authorBarry, Alison
dc.contributor.authorCronin, Owen
dc.contributor.authorRyan, Aisling M.
dc.contributor.authorSweeney, Brian
dc.contributor.authorO'Toole, Orna
dc.contributor.authorO'Halloran, Ken D.
dc.contributor.authorDowner, Eric J.
dc.contributor.funderPhysiological Society of Irelanden
dc.contributor.funderUniversity College Corken
dc.date.accessioned2019-06-17T15:23:44Z
dc.date.available2019-06-17T15:23:44Z
dc.date.issued2019-04-30
dc.date.updated2019-06-17T15:15:23Z
dc.description.abstractThe objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.en
dc.description.sponsorshipUniversity College Cork (UCC School of Medicine Translational Research Access Programme; UCC Strategic Research Fund; Department of Physiology, UCC)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBarry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D. and Downer, E. J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis', Neurological Sciences, doi: 10.1007/s10072-019-03915-2en
dc.identifier.doi10.1007/s10072-019-03915-2en
dc.identifier.endpage4en
dc.identifier.issn1590-1874
dc.identifier.journaltitleNeurological Sciencesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8060
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs10072-019-03915-2
dc.rights© Fondazione Società Italiana di Neurologia 2019. This is a post-peer-review, pre-copyedit version of an article published in Neurological Sciences. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10072-019-03915-2en
dc.subjectMultiple sclerosisen
dc.subjectExerciseen
dc.subjectCytokinesen
dc.subjectPlasma Interleukin-10en
dc.titleCycle ergometer training enhances plasma interleukin-10 in multiple sclerosisen
dc.typeArticle (peer-reviewed)en
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