Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

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dc.check.date2020-04-30
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorBarry, Alison
dc.contributor.authorCronin, Owen
dc.contributor.authorRyan, Aisling M.
dc.contributor.authorSweeney, Brian
dc.contributor.authorO'Toole, Orna
dc.contributor.authorO'Halloran, Ken D.
dc.contributor.authorDowner, Eric J.
dc.contributor.funderPhysiological Society of Irelanden
dc.contributor.funderUniversity College Corken
dc.date.accessioned2019-06-17T15:23:44Z
dc.date.available2019-06-17T15:23:44Z
dc.date.issued2019-04-30
dc.date.updated2019-06-17T15:15:23Z
dc.description.abstractThe objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.en
dc.description.sponsorshipUniversity College Cork (UCC School of Medicine Translational Research Access Programme; UCC Strategic Research Fund; Department of Physiology, UCC)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBarry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D. and Downer, E. J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis', Neurological Sciences, doi: 10.1007/s10072-019-03915-2en
dc.identifier.doi10.1007/s10072-019-03915-2en
dc.identifier.endpage4en
dc.identifier.issn1590-1874
dc.identifier.journaltitleNeurological Sciencesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8060
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs10072-019-03915-2
dc.rights© Fondazione Società Italiana di Neurologia 2019. This is a post-peer-review, pre-copyedit version of an article published in Neurological Sciences. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10072-019-03915-2en
dc.subjectMultiple sclerosisen
dc.subjectExerciseen
dc.subjectCytokinesen
dc.subjectPlasma Interleukin-10en
dc.titleCycle ergometer training enhances plasma interleukin-10 in multiple sclerosisen
dc.typeArticle (peer-reviewed)en
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