Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis
dc.contributor.author | Barry, Alison | |
dc.contributor.author | Cronin, Owen | |
dc.contributor.author | Ryan, Aisling M. | |
dc.contributor.author | Sweeney, Brian | |
dc.contributor.author | O'Toole, Orna | |
dc.contributor.author | O'Halloran, Ken D. | |
dc.contributor.author | Downer, Eric J. | |
dc.contributor.funder | Physiological Society of Ireland | en |
dc.contributor.funder | University College Cork | en |
dc.date.accessioned | 2019-06-17T15:23:44Z | |
dc.date.available | 2019-06-17T15:23:44Z | |
dc.date.issued | 2019-04-30 | |
dc.date.updated | 2019-06-17T15:15:23Z | |
dc.description.abstract | The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS. | en |
dc.description.sponsorship | University College Cork (UCC School of Medicine Translational Research Access Programme; UCC Strategic Research Fund; Department of Physiology, UCC) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Barry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D. and Downer, E. J. (2019) 'Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis', Neurological Sciences, doi: 10.1007/s10072-019-03915-2 | en |
dc.identifier.doi | 10.1007/s10072-019-03915-2 | en |
dc.identifier.endpage | 4 | en |
dc.identifier.issn | 1590-1874 | |
dc.identifier.journaltitle | Neurological Sciences | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/8060 | |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.relation.uri | https://link.springer.com/article/10.1007%2Fs10072-019-03915-2 | |
dc.rights | © Fondazione Società Italiana di Neurologia 2019. This is a post-peer-review, pre-copyedit version of an article published in Neurological Sciences. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10072-019-03915-2 | en |
dc.subject | Multiple sclerosis | en |
dc.subject | Exercise | en |
dc.subject | Cytokines | en |
dc.subject | Plasma Interleukin-10 | en |
dc.title | Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis | en |
dc.type | Article (peer-reviewed) | en |