Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis

Manzari, Nicla; Matvienko-Sikar, Karen; Baldoni, Franco; O'Keeffe, Gerard W.; Khashan, Ali S.

Access to this article is restricted until 12 months after publication by request of the publisher.. Restriction lift date: 2020-07-20

Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis

Simple item page

dc.check.date	2020-07-20
dc.check.info	Access to this article is restricted until 12 months after publication by request of the publisher.	en
dc.contributor.author	Manzari, Nicla
dc.contributor.author	Matvienko-Sikar, Karen
dc.contributor.author	Baldoni, Franco
dc.contributor.author	O'Keeffe, Gerard W.
dc.contributor.author	Khashan, Ali S.
dc.contributor.funder	Science Foundation Ireland	en
dc.date.accessioned	2019-08-08T09:02:04Z
dc.date.available	2019-08-08T09:02:04Z
dc.date.issued	2019-07-20
dc.date.updated	2019-08-08T08:44:06Z
dc.description.abstract	Purpose: Exposure to prenatal stress has been reported to affect the risk of adverse neurodevelopmental outcomes in the offspring; however, there is currently no clear consensus. The aim of this systematic review and meta-analysis was to examine the existing literature on the association between prenatal stress and autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in the offspring. Methods: Based on a registered protocol, we searched several electronic databases for articles in accordance with a detailed search strategy. We performed this study following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Results: Prenatal stress was significantly associated with an increased risk of both ASD (pooled OR 1.64 [95% CI 1.15–2.34]; I2 = 90%; 15 articles) and ADHD (pooled OR 1.72 [95% CI 1.27–2.34]; I2 = 85%; 12 articles). Conclusions: This study suggests that prenatal stress may be associated with ASD and ADHD; however, several limitations in the reviewed literature should be noted including significant heterogeneity and there is a need for carefully controlled future studies in this area.	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Manzari, N., Matvienko-Sikar, K., Baldoni, F., O'Keeffe, G. W. and Khashan, A. S. (2019) 'Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis', Social Psychiatry and Psychiatric Epidemiology. doi: 10.1007/s00127-019-01745-3	en
dc.identifier.doi	10.1007/s00127-019-01745-3	en
dc.identifier.eissn	1433-9285
dc.identifier.endpage	11	en
dc.identifier.issn	0933-7954
dc.identifier.journaltitle	Social Psychiatry and Psychiatric Epidemiology	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/8296
dc.language.iso	en	en
dc.publisher	Springer Nature Switzerland AG	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/	en
dc.rights	© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Social Psychiatry and Psychiatric Epidemiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00127-019-01745-3	en
dc.subject	Autism spectrum disorder	en
dc.subject	Attention-deficit/hyperactivity disorder Prenatal maternal stress	en
dc.subject	Pregnancy	en
dc.subject	Mental health	en
dc.title	Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis	en
dc.type	Article (peer-reviewed)	en