Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota

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dc.contributor.authorRobertson, Ruairi C.
dc.contributor.authorKaliannan, Kanakaraju
dc.contributor.authorStrain, Conall R.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorStanton, Catherine
dc.contributor.authorKang, Jing X.
dc.contributor.funderFortune Education Foundationen
dc.contributor.funderSansun Life Sciencesen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderMarine Instituteen
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderTeagascen
dc.contributor.funderThe Fulbright Commission of Irelanden
dc.date.accessioned2019-07-18T12:01:51Z
dc.date.available2019-07-18T12:01:51Z
dc.date.issued2018-05-24
dc.description.abstractBackground: The early-life gut microbiota plays a critical role in host metabolism in later life. However, little is known about how the fatty acid profile of the maternal diet during gestation and lactation influences the development of the offspring gut microbiota and subsequent metabolic health outcomes. Results: Here, using a unique transgenic model, we report that maternal endogenous n-3 polyunsaturated fatty acid (PUFA) production during gestation or lactation significantly reduces weight gain and markers of metabolic disruption in male murine offspring fed a high-fat diet. However, maternal fatty acid status appeared to have no significant effect on weight gain in female offspring. The metabolic phenotypes in male offspring appeared to be mediated by comprehensive restructuring of gut microbiota composition. Reduced maternal n-3 PUFA exposure led to significantly depleted Epsilonproteobacteria, Bacteroides, and Akkermansia and higher relative abundance of Clostridia. Interestingly, offspring metabolism and microbiota composition were more profoundly influenced by the maternal fatty acid profile during lactation than in utero. Furthermore, the maternal fatty acid profile appeared to have a long-lasting effect on offspring microbiota composition and function that persisted into adulthood after life-long high-fat diet feeding. Conclusions: Our data provide novel evidence that weight gain and metabolic dysfunction in adulthood is mediated by maternal fatty acid status through long-lasting restructuring of the gut microbiota. These results have important implications for understanding the interaction between modern Western diets, metabolic health, and the intestinal microbiome.en
dc.description.sponsorshipHealth Research Board (POR/2011/23; POR/2012/32); Marine Institute, Department of Agriculture, Food and the Marine (TODDLERFOOD; Nutramara (MFFRI/07/01), SMART FOOD Project (Science Based ‘Intelligent’/Functional and Medical Foods for Optimum Brain Health, Targeting Depression and Cognition” project (Ref No. 13/F/411); Teagasc (Walsh Fellowship)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid95en
dc.identifier.citationRobertson, R.C., Kaliannan, K., Strain, C.R., Ross, R.P., Stanton, C. and Kang, J.X., 2018. Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota. Microbiome, 6(1): 95. DOI: 10.1186/s40168-018-0476-6en
dc.identifier.doi10.1186/s40168-018-0476-6en
dc.identifier.eissn2049-2618
dc.identifier.endpage14en
dc.identifier.issued1en
dc.identifier.journaltitleMicrobiomeen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8202
dc.identifier.volume6en
dc.language.isoenen
dc.publisherBMCen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0476-6
dc.relation.urihttps://doi.org/10.6084/m9.figshare.5166502.v8
dc.rights© 2018 The Author(s)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiomeen
dc.subjectMicrobiotaen
dc.subjectn-3 PUFAen
dc.subjectObesityen
dc.subjectMaternal dieten
dc.titleMaternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiotaen
dc.typeArticle (peer-reviewed)en
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