Gut microbiota composition is associated with temperament traits in infants

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dc.contributor.authorAatsinki, Anna-Katariina
dc.contributor.authorLahti, Leo
dc.contributor.authorUusitupa, Henna-Maria
dc.contributor.authorMunukka, Eveliina
dc.contributor.authorKeskitalo, Anniina
dc.contributor.authorCaballero-Fonseca, F.
dc.contributor.authorO'Mahony, Siobhain
dc.contributor.authorPietilä, Sami
dc.contributor.authorElo, Laura L.
dc.contributor.authorEerola, Erkki
dc.contributor.authorKarlsson, Hasse
dc.contributor.authorKarlsson, Linnea
dc.contributor.funderAcademy of Finlanden
dc.contributor.funderYrjö Jahnssonin Säätiöen
dc.contributor.funderSigne ja Ane Gyllenbergin Säätiöen
dc.contributor.funderState Funding, Finlanden
dc.date.accessioned2019-11-20T05:55:12Z
dc.date.available2019-11-20T05:55:12Z
dc.date.issued2019-05-24
dc.description.abstractBackground: One of the key behavioral phenotypes in infancy are different temperament traits, and certain early life temperament traits have been shown to precede later mental health problems. Differences in the gut microbiota composition (GMC) have been suggested to link with neurodevelopment. For example, toddler temperament traits have been found to associate with differences in GMC; however, studies in infants are lacking although infancy is a rapid period of neurodevelopment as well as GM development. Thus, we aimed to investigate association between infant GMC and temperament. Methods: The study population (n = 301, 53% boys) was drawn from the FinnBrain Birth Cohort Study. Stool samples were collected from the 2.5-month-old infants and sequenced with 16S Illumina MiSeq platform. GMC taxonomic composition (at Genus and OTU level), observed sample clusters, diversity and richness were investigated in relation to the maternal reports of Infant Behavior Questionnaire -Revised (IBQ-R) at the age of 6 months. Results: Three sample clusters (Bifidobacterium/Enterobacteriaceae, Bacteroides, V. Dispar) based on GMC were identified, of which Bifidobacterium/Enterobacteriaceae–cluster presented with higher scores on the IBQ-R main dimension regulation and its subscale duration of orienting compared to Bacteroides-cluster. The clusters associated with temperament in a sex-dependent manner. The IBQ-R main dimension surgency (positive emotionality) was associated positively both with genus Bifidobacterium and Streptococcus. Alpha diversity had a negative association with negative emotionality and fear reactivity. Conclusion This is the first study demonstrating associations, but not causal connections, between GMC and temperament in young infants in a prospective design.en
dc.description.sponsorshipAcademy of Finland (307127)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAatsinki, A.K., Lahti, L., Uusitupa, H.M., Munukka, E., Keskitalo, A., Nolvi, S., O'Mahony, S., Pietilä, S., Elo, L.L., Eerola, E. and Karlsson, H. (2019) 'Gut microbiota composition is associated with temperament traits in infants. Brain, behavior, and immunity', 80, pp.849-858. doi:10.1016/j.bbi.2019.05.035en
dc.identifier.doi10.1016/j.bbi.2019.05.035en
dc.identifier.eissn1090-2139
dc.identifier.endpage858en
dc.identifier.issn0889-1591
dc.identifier.journaltitleBrain, Behavior, and Immunityen
dc.identifier.startpage849en
dc.identifier.urihttps://hdl.handle.net/10468/9146
dc.identifier.volume80en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/AKA//308176/FI/Early life stress, gut microbiome, and child brain development - the FinnBrain Birth Cohort Study/en
dc.relation.projectinfo:eu-repo/grantAgreement/AKA//264363/FI/Quality of day-care and the risk of social exclusion in early childhood / Consortium: FinnBrain-LASSO/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/253770/EU/Paediatric Medical Trust/PMTen
dc.relation.projectinfo:eu-repo/grantAgreement/AKA//134950/FI/Stress, attachment and the developing brain / Consortium: SADBrain/en
dc.relation.projectinfo:eu-repo/grantAgreement/AKA//295741/FI/Ecological modeling of the human gut microbiome: individuality, dynamics, and function in large population cohorts/en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0889159119300777
dc.rights© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGut microbiotaen
dc.subjectInfanten
dc.subjectBehavioral phenotypesen
dc.subjectTemperament traitsen
dc.titleGut microbiota composition is associated with temperament traits in infantsen
dc.typeArticle (peer-reviewed)en
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