Maternal mid-gestation cytokine dysregulation in mothers of children with autism spectrum disorder

dc.contributor.authorCasey, Sophieen
dc.contributor.authorCarter, Michaelen
dc.contributor.authorLooney, Ann-Marieen
dc.contributor.authorLivingstone, Vickien
dc.contributor.authorMoloney, Gerard M.en
dc.contributor.authorO'Keeffe, Gerard W. en
dc.contributor.authorTaylor, Rennae S.en
dc.contributor.authorKenny, Louise C.en
dc.contributor.authorMcCarthy, Fergus P.en
dc.contributor.authorMcCowan, Lesley M. E.en
dc.contributor.authorThompson, John M. D.en
dc.contributor.authorMurray, Deirdre M.en
dc.contributor.authorSCOPE Consortium
dc.contributor.funderIrish Research Councilen
dc.contributor.funderNational Children's Research Centre, Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Board of Irelanden
dc.contributor.funderNew Enterprise Research Fund, New Zealanden
dc.contributor.funderFoundation for Research, Science and Technologyen
dc.contributor.funderHealth Research Council of New Zealanden
dc.contributor.funderEvelyn Bond Fund, New Zealanden
dc.contributor.funderAuckland District Health Board Charitable Trust, New Zealanden
dc.date.accessioned2024-05-15T11:23:43Z
dc.date.available2024-05-15T11:23:43Z
dc.date.issued2021-09-09en
dc.description.abstractAutism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.en
dc.description.sponsorshipIrish Research Council (GOIPG/2017/1350); National Children’s Research Centre, Ireland (Clinical Research Fellowship D/19/1); Health Research Board of Ireland ((CSA/2012/40); Irish SCOPE study was funded by Health Research Board of Ireland (CSA/2007/2)); Science Foundation Ireland (SFI Research Centre Award 12/RC/2272); New Enterprise Research Fund, Foundation for Research Science and Technology (The NZ SCOPE study); Health Research Council (04/198); Evelyn Bond Fund, Auckland District Health Board Charitable Trust.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCasey, S., Carter, M., Looney, A.M., Livingstone, V., Moloney, G., O’Keeffe, G.W., Taylor, R.S., Kenny, L.C., McCarthy, F.P., McCowan, L.M.E., Thompson, J.M.D., Murray, D.M., and the SCOPE Consortium (2022) ‘Maternal mid-gestation cytokine dysregulation in mothers of children with autism spectrum disorder’, Journal of Autism and Developmental Disorders, 52(9), pp. 3919–3932. Available at: https://doi.org/10.1007/s10803-021-05271-7en
dc.identifier.doihttps://doi.org/10.1007/s10803-021-05271-7en
dc.identifier.endpage3932en
dc.identifier.issn0162-3257en
dc.identifier.issn1573-3432en
dc.identifier.issued9en
dc.identifier.journaltitleJournal of Autism and Developmental Disordersen
dc.identifier.startpage3919en
dc.identifier.urihttps://hdl.handle.net/10468/15868
dc.identifier.volume52en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofJournal of Autism and Developmental Disordersen
dc.rights© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectIL-17Aen
dc.subjectAutism spectrum disorderen
dc.subjectCytokine Inflammationen
dc.subjectMaternal immune activationen
dc.titleMaternal mid-gestation cytokine dysregulation in mothers of children with autism spectrum disorderen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue9en
oaire.citation.volume52en
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