Maternal mid-gestation cytokine dysregulation in mothers of children with autism spectrum disorder

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Date
2021-09-09
Authors
Casey, Sophie
Carter, Michael
Looney, Ann-Marie
Livingstone, Vicki
Moloney, Gerard M.
O'Keeffe, Gerard W.
Taylor, Rennae S.
Kenny, Louise C.
McCarthy, Fergus P.
McCowan, Lesley M. E.
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Springer
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Abstract
Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.
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Keywords
IL-17A , Autism spectrum disorder , Cytokine Inflammation , Maternal immune activation
Citation
Casey, S., Carter, M., Looney, A.M., Livingstone, V., Moloney, G., O’Keeffe, G.W., Taylor, R.S., Kenny, L.C., McCarthy, F.P., McCowan, L.M.E., Thompson, J.M.D., Murray, D.M., and the SCOPE Consortium (2022) ‘Maternal mid-gestation cytokine dysregulation in mothers of children with autism spectrum disorder’, Journal of Autism and Developmental Disorders, 52(9), pp. 3919–3932. Available at: https://doi.org/10.1007/s10803-021-05271-7
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