Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish

Simple item page
dc.contributor.authorBorrelli, Luca
dc.contributor.authorAceto, Serena
dc.contributor.authorAgnisola, Claudio
dc.contributor.authorDe Paolo, Sofia
dc.contributor.authorDipineto, Ludovico
dc.contributor.authorStilling, Roman M.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.authorMenna, Lucia F.
dc.contributor.funderRegione Campania
dc.date.accessioned2017-06-22T13:55:53Z
dc.date.available2017-06-22T13:55:53Z
dc.date.issued2016-07-15
dc.description.abstractThe gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication that integrates the gut and central nervous system (CNS) activities. Animal studies reveal that gut bacteria influence behaviour, Brain-Derived Neurotrophic Factor (BDNF) levels and serotonin metabolism. In the present study, we report for the first time an analysis of the microbiota–gut–brain axis in zebrafish (Danio rerio). After 28 days of dietary administration with the probiotic Lactobacillus rhamnosus IMC 501, we found differences in shoaling behaviour, brain expression levels of bdnf and of genes involved in serotonin signalling/metabolism between control and treated zebrafish group. In addition, in microbiota we found a significant increase of Firmicutes and a trending reduction of Proteobacteria. This study demonstrates that selected microbes can be used to modulate endogenous neuroactive molecules in zebrafish.en
dc.description.sponsorshipRegione Campania (Fondo Sociale Europeo 2007/2013)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid30046
dc.identifier.citationBorrelli, L., Aceto, S., Agnisola, C., De Paolo, S., Dipineto, L., Stilling, R. M., Dinan, T. G., Cryan, J. F., Menna, L. F. and Fioretti, A. (2016) 'Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish', Scientific Reports, 6, 30046 (9pp). doi: 10.1038/srep30046en
dc.identifier.doi10.1038/srep30046
dc.identifier.endpage9
dc.identifier.issn2045-2322
dc.identifier.journaltitleScientific Reportsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/4169
dc.identifier.volume6
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urihttps://www.nature.com/articles/srep30046
dc.rights© 2016, Borrelli et al. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiomeen
dc.subjectNutritionen
dc.titleProbiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafishen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 3 of 3
Thumbnail Image
Name:
3030.pdf
Size:
745.94 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Thumbnail Image
Name:
3030-1.pdf
Size:
591.55 KB
Format:
Adobe Portable Document Format
Description:
Supplementary File 1
Download
Thumbnail Image
Name:
3030-2.avi
Size:
23.69 MB
Format:
Unknown data format
Description:
Supplementary File 2
Download
Collections
APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles
Psychiatry - Journal Articles