Gut microbiome effects on neuronal excitability and activity: Implications for epilepsy

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dc.contributor.authorDarch, Henryen
dc.contributor.authorMcCafferty, Cian P.en
dc.contributor.funderHorizon 2020en
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-06-01T12:17:15Z
dc.date.available2023-06-01T12:17:15Z
dc.date.issued2022-01-24en
dc.description.abstractIt is now well established that the bacterial population of the gastrointestinal system, known as the gut microbiome, is capable of influencing the brain and its dependent functions. Links have been demonstrated between the microbiome and a variety of normal and pathological neural functions, including epilepsy. Many of these microbiome-brain links involve the direct or indirect modulation of the excitability and activity of individual neurons by the gut microbiome. Such links may be particularly significant when it comes to microbiome modulation of epilepsy, often considered a disorder of neuronal excitability. In this review we consider the current evidence of a relationship between the gut microbiome and the excitability or activity of neurons in the context of epilepsy. The review focuses particularly on evidence of direct, causal microbiome effects on neuronal excitability or activity, but also considers demonstrations of microbiome to host interactions that are likely to have an indirect influence. While we identify a few common themes, it is apparent that deriving general mechanistic principles of microbiome influence on these parameters in epilepsy will require considerable further study to tease out the many interacting factors, systems, and conditions.en
dc.description.sponsorshipScience Foundation Ireland (Grant SF1/12/RC/2273 P2)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid105629en
dc.identifier.citationDarch, H. and McCafferty, C. P. (2022) 'Gut microbiome effects on neuronal excitability and activity: Implications for epilepsy', Neurobiology of Disease, 165, 105629 (9pp). doi: 10.1016/j.nbd.2022.105629en
dc.identifier.doi10.1016/j.nbd.2022.105629en
dc.identifier.endpage9en
dc.identifier.issn0969-9961en
dc.identifier.journaltitleNeurobiology of Diseaseen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14537
dc.identifier.volume165en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.rights© 2022, the Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectEpilepsyen
dc.subjectMicrobiomeen
dc.subjectExcitabilityen
dc.subjectMicrobiota-gut-brain axisen
dc.subjectMicrobiotaen
dc.subjectSeizureen
dc.subjectParoxysmen
dc.subjectOscillationen
dc.subjectNeuronal activityen
dc.titleGut microbiome effects on neuronal excitability and activity: Implications for epilepsyen
dc.typeArticle (peer-reviewed)en
oaire.citation.volume165en
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