Microbial memories: sex-dependent impact of the gut microbiome on hippocampal plasticity

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dc.contributor.authorDarch, Henry T.
dc.contributor.authorCollins, Michael K.
dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSaks-Kavanaugh Foundationen
dc.date.accessioned2022-04-05T15:34:31Z
dc.date.available2022-04-05T15:34:31Z
dc.date.issued2021-08
dc.date.updated2022-04-05T15:18:21Z
dc.description.abstractGerm-free rodents, raised in the absence of a measurable gut microbiome, have been a key model to study the microbiome-gut-brain axis. Germ-free mice exhibit marked behavioural and neurochemical differences to their conventionally raised counterparts. It is as yet unclear how these neurochemical differences lead to the behavioural differences. Here, we test the electrophysiological properties of hippocampal plasticity in adult germ-free mice and compare them to conventionally raised counterparts. Whilst basal synaptic efficacy and pre-synaptic short-term plasticity appear normal, we find a striking alteration of hippocampal long-term potentiation specifically in male germ-free slices. However, the spike output of these neurons remains normal along with altered input-output coupling, potentially indicating homeostatic compensatory mechanisms, or an altered excitation/inhibition balance. To our knowledge this is the first time the electrophysiological properties of the hippocampus have been assessed in a microbiome deficient animal. Our data indicate that the absence of a microbiome alters integration of dendritic signalling in the CA1 region in mice.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDarch, H. T., Collins, M. K., O'Riordan, K. J. and Cryan, J. F. (2021) 'Microbial memories: sex-dependent impact of the gut microbiome on hippocampal plasticity', The European Journal of Neuroscience, 54 (4) pp. 5235-5244. doi: 10.1111/ejn.15119.en
dc.identifier.doi10.1111/ejn.15119en
dc.identifier.endpage5244en
dc.identifier.issn0953-816X
dc.identifier.issued4en
dc.identifier.journaltitleThe European Journal of Neuroscienceen
dc.identifier.startpage5235en
dc.identifier.urihttps://hdl.handle.net/10468/13034
dc.identifier.volume54en
dc.language.isoenen
dc.publisherJohn Wiley and Sons Ltden
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectLong-term potentiationen
dc.subjectAnxiety-like behavioren
dc.subjectSynaptic plasticityen
dc.subjectCognitive deficitsen
dc.subjectStressen
dc.subjectDysfunctionen
dc.subjectExpressionen
dc.subjectMiceen
dc.subjectImpairmenten
dc.subjectActivationen
dc.titleMicrobial memories: sex-dependent impact of the gut microbiome on hippocampal plasticityen
dc.typeArticle (peer-reviewed)en
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