Vitamin D and muscle strength throughout the life course: a review of epidemiological and intervention studies.

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dc.contributor.authorMcCarthy, Elaine K.
dc.contributor.authorKiely, Mairead E.
dc.date.accessioned2019-02-19T14:29:00Z
dc.date.available2019-02-19T14:29:00Z
dc.date.issued2014-10-03
dc.date.updated2019-02-19T14:23:11Z
dc.description.abstractThe putative role of vitamin D in muscle function and strength throughout the life course is of interest because muscle strength is required for engagement in physical activity at all ages. As vitamin D deficiency is widely reported in the population, especially in countries at high latitude, the potential importance of vitamin D in muscle function throughout life, and the potential impacts on growth and development, participation in physical activity, and effects on skeletal and cardio‐metabolic health, comprise an important topic for discussion. This review provides an overview of muscle function and summarises the role of the vitamin D receptor and the proposed molecular mechanisms of action of vitamin D in muscle cells. In addition, the review provides a comprehensive assessment of the clinical evidence surrounding the association between vitamin D and muscle strength. Among adults, particularly older adults, cross‐sectional and cohort studies reported a positive association between vitamin D status and muscle strength. These associations have been largely confirmed by intervention studies. Limited research has been carried out in adolescents and children; two cross‐sectional studies in adolescents have suggested an association between serum 25‐hydroxyvitamin D concentrations and muscle strength. However, the two intervention studies in adolescents have yielded conflicting results. Other than a single observational study, data in young children are very limited and further investigation in under 12‐year‐olds is warranted.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcCarthy, E. K. and Kiely, M. (2015) 'Vitamin D and muscle strength throughout the life course: a review of epidemiological and intervention studies', Journal of Human Nutrition and Dietetics, 28(6), pp. 636-645. doi: 10.1111/jhn.12268en
dc.identifier.doi10.1111/jhn.12268
dc.identifier.endpage645en
dc.identifier.issn0952-3871
dc.identifier.journaltitleJournal of Human Nutrition and Dieteticsen
dc.identifier.startpage636en
dc.identifier.urihttps://hdl.handle.net/10468/7522
dc.identifier.volume28en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/jhn.12268
dc.rights© 2014 The British Dietetic Association Ltd. This is the peer reviewed version of the following article: McCarthy E.K. & Kiely M. (2015) Vitamin D and muscle strength throughout the life course: a review of epidemiological and intervention studies. J Hum Nutr Diet. 28, 636–645, which has been published in final form at https://doi.org/10.1111/jhn.12268. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectMuscle functionen
dc.subjectMuscle strengthen
dc.subjectVitamin Den
dc.subjectVitamin D deficiencyen
dc.subjectVitamin D receptoren
dc.titleVitamin D and muscle strength throughout the life course: a review of epidemiological and intervention studies.en
dc.typeArticle (peer-reviewed)en
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