Genetic variants related to urate and risk of Parkinson's disease

Simple item page
dc.check.date2019-05-01
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorHughes, Katherine C.
dc.contributor.authorGao, Xiang
dc.contributor.authorO'Reilly, Éilis J.
dc.contributor.authorKim, Iris Y.
dc.contributor.authorWang, Molin
dc.contributor.authorWeisskopf, Marc G.
dc.contributor.authorSchwarzschild, Michael A.
dc.contributor.authorAscherio, Alberto
dc.contributor.funderNational Institutes of Healthen
dc.contributor.funderU.S. Department of Defenseen
dc.date.accessioned2018-05-24T15:32:38Z
dc.date.available2018-05-24T15:32:38Z
dc.date.issued2018-05-01
dc.description.abstractIntroduction: Higher urate concentrations have been associated with a lower risk of developing Parkinson's disease (PD) and with slower rates of clinical decline in PD patients. Whether these associations reflect a neuroprotective effect of urate is unclear. Our objective was to assess whether genetic variants that modify circulating urate levels are also associated with altered PD risk. Methods: Participants were from three large ongoing cohort studies: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Cancer Prevention Study II Nutrition Cohort (CPS-IIN). We examined associations between single nucleotide polymorphisms (SNPs) in SLC2A9 and other genes involved in urate transport and PD risk using conditional logistic regression among 1451 cases and 3135 matched controls. We assessed associations between SNPs and plasma urate levels in a subset of 1174 control participants with linear regression models. Results: We found the expected associations between SNPs in SLC2A9 and plasma urate levels among men and women; however, SNPs in other genes tended not to be associated with urate. Each SNP in SLC2A9 explained less than 7% of the variance in plasma urate. We did not find significant associations between the SNPs in SLC2A9 and PD risk among men or women. Conclusion: Our results do not support an association between genetic variants associated with circulating urate levels and risk of PD, but larger investigations are needed to determine whether the modest genetic effects on blood urate contribute to predict PD risk.en
dc.description.sponsorshipU.S. Department of Defense (W81XWH-14-0131)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHughes, K. C., Gao, X., O'Reilly, E. J., Kim, I. Y., Wang, M., Weisskopf, M. G., Schwarzschild, M. A. and Ascherio, A. (2018) 'Genetic variants related to urate and risk of Parkinson's disease', Parkinsonism & Related Disorders, In Press. doi: 10.1016/j.parkreldis.2018.04.031en
dc.identifier.doi10.1016/j.parkreldis.2018.04.031
dc.identifier.endpage6en
dc.identifier.issn1353-8020
dc.identifier.journaltitleParkinsonism & Related Disordersen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/6191
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/5UM1CA186107-02/US/Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study/en
dc.relation.projectinfo:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE/5R01NS061858-03/US/Urate as a Predictor of Parkinsons Disease Risk and Progression/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1353802018302190
dc.rights© 2018 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectParkinson's diseaseen
dc.subjectUrateen
dc.subjectCohort studiesen
dc.subjectUrate levelsen
dc.titleGenetic variants related to urate and risk of Parkinson's diseaseen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
5562.pdf
Size:
509.17 KB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Public Health - Journal Articles