A good start in life is important-perinatal factors dictate early microbiota development and longer term maturation

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dc.contributor.authorWang, Shaopu
dc.contributor.authorEgan, Muireann
dc.contributor.authorRyan, Anthony C.
dc.contributor.authorBoyaval, Patrick
dc.contributor.authorDempsey, Eugene M.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorStanton, Catherine
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderDuPonten
dc.date.accessioned2022-06-09T11:41:48Z
dc.date.available2022-06-09T11:41:48Z
dc.date.issued2020-11
dc.date.updated2022-06-09T11:14:24Z
dc.description.abstractMaternal health status is vital for the development of the offspring of humans, including physiological health and psychological functions. The complex and diverse microbial ecosystem residing within humans contributes critically to these intergenerational impacts. Perinatal factors, including maternal nutrition, antibiotic use and maternal stress, alter the maternal gut microbiota during pregnancy, which can be transmitted to the offspring. In addition, gestational age at birth and mode of delivery are indicated frequently to modulate the acquisition and development of gut microbiota in early life. The early-life gut microbiota engages in a range of host biological processes, particularly immunity, cognitive neurodevelopment and metabolism. The perturbed early-life gut microbiota increases the risk for disease in early and later life, highlighting the importance of understanding relationships of perinatal factors with early-life microbial composition and functions. In this review, we present an overview of the crucial perinatal factors and summarise updated knowledge of early-life microbiota, as well as how the perinatal factors shape gut microbiota in short and long terms. We further discuss the clinical consequences of perturbations of early-life gut microbiota and potential therapeutic interventions with probiotics/live biotherapeutics.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWang, S., Egan, M., Ryan, A. C., Boyaval, P., Dempsey, E. M., Ross, R. P. and Stanton, C. (2020) 'A good start in life is important-perinatal factors dictate early microbiota development and longer term maturation', FEMS Microbiology Reviews, 44 (6), pp. 763-781. doi: 10.1093/femsre/fuaa030en
dc.identifier.doi10.1093/femsre/fuaa030en
dc.identifier.endpage781en
dc.identifier.issn0168-6445
dc.identifier.issued6en
dc.identifier.journaltitleFEMS Microbiology Reviewsen
dc.identifier.startpage763en
dc.identifier.urihttps://hdl.handle.net/10468/13291
dc.identifier.volume44en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights©The Author(s) 2020. Published by Oxford University Press on behalf of FEMS. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/)en
dc.subjectHuman gut microbiomeen
dc.subjectIntrapartum antibiotic-prophylaxisen
dc.subjectHuman-milk microbiomeen
dc.subjectIntestinal microbiotaen
dc.subjectCesarean-sectionen
dc.subjectBreast-milken
dc.subjectFecal microbiotaen
dc.subjectNecrotizing enterocolitisen
dc.subjectProbiotic supplementationen
dc.subjectAtopic-dermatitisen
dc.titleA good start in life is important-perinatal factors dictate early microbiota development and longer term maturationen
dc.typeArticle (peer-reviewed)en
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