dc.contributor.author	Gururajan, Anand
dc.contributor.author	van de Wouw, Marcel
dc.contributor.author	Boehme, Marcus
dc.contributor.author	Becker, Thorsten
dc.contributor.author	O'Connor, Rory
dc.contributor.author	Bastiaanssen, Thomaz F. S.
dc.contributor.author	Moloney, Gerard M.
dc.contributor.author	Lyte, Joshua M.
dc.contributor.author	Ventura-Silva, Ana Paula
dc.contributor.author	Merckx, Barbara
dc.contributor.author	Dinan, Timothy G.
dc.contributor.author	Cryan, John F.
dc.contributor.funder	Horizon 2020	en
dc.contributor.funder	Science Foundation Ireland	en
dc.contributor.funder	Health Research Board	en
dc.contributor.funder	Enterprise Ireland	en
dc.contributor.funder	Department of Agriculture, Food and the Marine	en
dc.date.accessioned	2019-06-07T09:23:11Z
dc.date.available	2019-06-07T09:23:11Z
dc.date.issued	2019-05-03
dc.date.updated	2019-06-07T09:07:59Z
dc.description.abstract	Research into the molecular basis of stress resilience is a novel strategy to identify potential therapeutic strategies to treat stress-induced psychopathologies such as anxiety and depression. Stress resilience is a phenomenon which is not solely driven by effects within the central nervous system (CNS) but involves multiple systems, central and peripheral, which interact with and influence each other. Accordingly, we used the chronic social defeat stress paradigm and investigated specific CNS, endocrine and immune responses to identify signatures of stress-resilience and stress susceptibility in mice. Our results showed that mice behaviourally susceptible to stress (indexed by a reduction in social interaction behaviour) had higher plasma corticosterone levels and adrenal hypertrophy. An increase in inflammatory circulating monocytes was another hallmark of stress susceptibility. Furthermore, prefrontal cortex mRNA expression of corticotrophin-releasing factor (Crf) was increased in susceptible mice relative to resilient mice. We also report differences in hippocampal synaptic plasticity between resilient and susceptible mice. Ongoing studies will interpret the functional relevance of these signatures which could potentially inform the development of novel psychotherapeutic strategies.	en
dc.description.sponsorship	Science Foundation Ireland (15/JP‐HDHL/3270; JPI‐HDHL‐NutriCog project ‘AMBROSIAC)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Gururajan, A., van de Wouw, M., Boehme, M., Becker, T., O'Connor, R., Bastiaanssen, T. F. S., Moloney, G. M., Lyte, J. M., Ventura Silva, A. P., Merckx, B., Dinan, T. G. and Cryan, J. F. (2019) 'Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses', Brain, Behavior, and Immunity. doi: 10.1016/j.bbi.2019.05.004	en
dc.identifier.doi	10.1016/j.bbi.2019.05.004	en
dc.identifier.eissn	1090-2139
dc.identifier.issn	0889-1591
dc.identifier.journaltitle	Brain, Behavior, and Immunity	en
dc.identifier.uri	https://hdl.handle.net/10468/8032
dc.language.iso	en	en
dc.publisher	Elsevier Inc.	en
dc.relation.project	info:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/704995/EU/Decoding Stress Resilience/DE-STRESS	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/	en
dc.relation.uri	http://www.sciencedirect.com/science/article/pii/S088915911830727X
dc.rights	© 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Stress resilience	en
dc.subject	Neuroendocrine	en
dc.subject	Corticotrophin-releasing factor	en
dc.subject	Prefrontal cortex	en
dc.subject	Synaptic plasticity	en
dc.subject	Inflammatory monocytes	en
dc.title	Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses	en
dc.type	Article (peer-reviewed)	en

Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses

Files

Original bundle

License bundle

Collections