Sarcopenia and cachexia in the era of obesity: Clinical and nutritional impact

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dc.contributor.authorPrado, C. M.
dc.contributor.authorCushen, Samantha J.
dc.contributor.authorOrsso C.
dc.contributor.authorRyan, Aoife M.
dc.date.accessioned2021-11-23T11:50:01Z
dc.date.available2021-11-23T11:50:01Z
dc.date.issued2016-01-08
dc.date.updated2021-11-23T11:35:51Z
dc.description.abstractOur understanding of body composition (BC) variability in contemporary populations has significantly increased with the use of imaging techniques. Abnormal BC such as sarcopenia (low muscle mass) and obesity (excess adipose tissue) are predictors of poorer prognosis in a variety of conditions or clinical situations. As a catabolic illness, a defining feature of cancer is muscle loss. Although the conceptual model of wasting in cancer is typically conceived as involuntary weight loss leading to low body weight, recent studies have shown that both sarcopenia and cachexia can be present with obesity. The combination of low muscle and high adipose tissue (sarcopenic obesity) is an emerging abnormal BC phenotype prevalent across the body weight, and hence BMI spectra. Sarcopenia and sarcopenic obesity in cancer are in most instances occult conditions, which have been independently associated with higher incidence of chemotherapy toxicity, shorter time to tumour progression, poorer outcomes of surgery, physical impairment and shorter survival. Although the mechanisms are yet to be fully understood, the associations with poorer clinical outcomes emphasise the value of nutritional assessment as well as the need to develop appropriate interventions to countermeasure abnormal BC. Sarcopenia and sarcopenic obesity create diverse nutritional requirements, highlighting the compelling need for a more comprehensive and differentiated understanding of energy and protein requirements in this heterogeneous population.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPrado, C. M., Cushen, S., Orsso C. and Ryan, A. M. (2016) 'Sarcopenia and cachexia in the era of obesity: Clinical and nutritional impact', Proceedings of the Nutrition Society, 75(2), pp. 188-198. doi: 10.1017/S0029665115004279en
dc.identifier.doi10.1017/S0029665115004279en
dc.identifier.eissn1475-2719
dc.identifier.endpage198en
dc.identifier.issn0029-6651
dc.identifier.issued2en
dc.identifier.journaltitleProceedings of the Nutrition Societyen
dc.identifier.startpage188en
dc.identifier.urihttps://hdl.handle.net/10468/12248
dc.identifier.volume75en
dc.language.isoenen
dc.publisherCambridge University Press on behalf of The Nutrition Societyen
dc.relation.ispartofThe Nutrition Society Irish Section Meeting, University College Cork, Cork, 16–19 June 2015
dc.relation.ispartofConference on ‘Nutrition at key life stages: new findings, new approaches’ Symposium 4: Clinical nutrition: gold standards and practical demonstrations
dc.rights© 2016, the Authors. Published by Cambridge University Press on behalf of The Nutrition Society. This material is free to view and download for personal use only. Not for re-distribution, re-sale or use in derivative works.en
dc.subjectSarcopeniaen
dc.subjectObesityen
dc.subjectSarcopenic obesityen
dc.subjectBody compositionen
dc.subjectNutritional assessmenten
dc.subjectCanceren
dc.subjectNutritional statusen
dc.subjectMuscleen
dc.subjectLean body massen
dc.subjectLean soft tissueen
dc.titleSarcopenia and cachexia in the era of obesity: Clinical and nutritional impacten
dc.typeArticle (peer-reviewed)en
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