Biosensors using photonic crystal fibres

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dc.check.embargoformatNot applicableen
dc.check.infoNo embargo requireden
dc.check.opt-outNot applicableen
dc.check.reasonNo embargo requireden
dc.check.typeNo Embargo Required
dc.contributor.advisorGunning, Fatima C. Garciaen
dc.contributor.advisorEllis, Andrew D.en
dc.contributor.authorRutowska, Monika S.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderThe OakWooden
dc.contributor.funderCompuserv GmbH, Germanyen
dc.date.accessioned2014-04-09T14:47:04Z
dc.date.available2014-04-09T14:47:04Z
dc.date.issued2014
dc.date.submitted2014
dc.description.abstractIn this thesis, we present the unique properties of hollow-core photonic crystal fibres (HC-PCFs) for sensing applications in terms of viscosity detection and DNA sensing using a special poly(ethylene) glycol (PEGDA) hydrogel. The low loss HC-PCFs ensure a long interaction length between the sample and the optical signals. Thus in this thesis, we report the characterisation of filled HC-PCFs and the development of a selective filling process. For the first time, we report the investigation of a new viscometer device, and a new device for DNA sensing development, and also the chemical process for hydrogel growth was adapted to the fibres. By combining HC-PCFs with the hydrogel we enable 3D volumetric sample confinement within the HC-PCF, further increasing the interaction between the sample and the optical signal. However, the hydrogel has a large influence on the guidance properties of the HC-PCF and the HC-PCF has a strong influence on the growth process for the hydrogel itself. When we integrate the hydrogel and HC-PCFs we detect concentration levels as low as 400 nM of labelled DNA. However, using our technology for fluorescence detection we can achieve results two orders of magnitude better than those previously reported.en
dc.description.sponsorshipScience Foundation Ireland (06/IN/1969)en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRutowska, M. S. 2014. Biosensors using photonic crystal fibres. PhD Thesis, University College Cork.en
dc.identifier.endpage152
dc.identifier.urihttps://hdl.handle.net/10468/1511
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2014, Monika S. Rutowskaen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectPhotonic crystal fibreen
dc.subjectSensingen
dc.subjectHydrogelen
dc.subjectViscosityen
dc.subject.lcshBiosensorsen
dc.subject.lcshPhotonicsen
dc.thesis.opt-outfalse
dc.titleBiosensors using photonic crystal fibresen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD (Science)en
ucc.workflow.supervisorfatima.gunning@tyndall.ie
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