dc.contributor.author	Hughes, Graham M.
dc.contributor.author	Leech, John
dc.contributor.author	Puechmaille, Sebastien J.
dc.contributor.author	Lopez, Jose V.
dc.contributor.author	Teeling, Emma C.
dc.contributor.funder	Conseil Régional de Bretagne
dc.contributor.funder	University College Dublin
dc.contributor.funder	European Research Council
dc.date.accessioned	2018-02-20T13:24:11Z
dc.date.available	2018-02-20T13:24:11Z
dc.date.issued	2018
dc.description.abstract	A changing microbiome has been linked to biological aging in mice and humans, suggesting a possible role of gut flora in pathogenic aging phenotypes. Many bat species have exceptional longevity given their body size and some can live up to ten times longer than expected with little signs of aging. This study explores the anal microbiome of the exceptionally long-lived Myotis myotis bat, investigating bacterial composition in both adult and juvenile bats to determine if the microbiome changes with age in a wild, long-lived non-model organism, using non-lethal sampling. The anal microbiome was sequenced using metabarcoding in more than 50 individuals, finding no significant difference between the composition of juvenile and adult bats, suggesting that age-related microbial shifts previously observed in other mammals may not be present in Myotis myotis. Functional gene categories, inferred from metabarcoding data, expressed in the M. myotis microbiome were categorized identifying pathways involved in metabolism, DNA repair and oxidative phosphorylation. We highlight an abundance of 'Proteobacteria' relative to other mammals, with similar patterns compared to other bat microbiomes. Our results suggest that M. myotis may have a relatively stable, unchanging microbiome playing a role in their extended 'health spans' with the advancement of age, and suggest a potential link between microbiome and sustained, powered flight.	en
dc.description.sponsorship	University College Dublin (Seed funding grant); Conseil Régional de Bretagne (Contrat Nature (‘Etude de la dynamique des populations de grand murin (Myotis myotis) en Bretagne et Pays de Loire’)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	e4174
dc.identifier.citation	Hughes, G. M., Leech, J., Puechmaille, S. J., Lopez, J. V. and Teeling, E. C. (2018) 'Is there a link between aging and microbiome diversity in exceptional mammalian longevity?', PeerJ, 6, e4174 (21pp). doi: 10.7717/peerj.4174	en
dc.identifier.doi	10.7717/peerj.4174
dc.identifier.endpage	21
dc.identifier.issn	2167-8359
dc.identifier.journaltitle	PeerJ	en
dc.identifier.startpage	1
dc.identifier.uri	https://hdl.handle.net/10468/5492
dc.identifier.volume	6
dc.language.iso	en	en
dc.publisher	PeerJ Inc.	en
dc.relation.project	info:eu-repo/grantAgreement/EC/FP7::SP2::ERC/311000/EU/Comparative genomics / ‘wildlife’ transcriptomics uncovers the mechanisms of halted ageing in mammals/AGELESS
dc.relation.uri	https://peerj.com/articles/4174/
dc.rights	© 2018, Hughes et al. Distributed under Creative Commons CC-BY 4.0 https://creativecommons.org/licenses/by/4.0/	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Gut microbiota	en
dc.subject	Host phylogeny	en
dc.subject	Bats	en
dc.subject	Conservation	en
dc.subject	Communities	en
dc.subject	Information	en
dc.subject	Evolution	en
dc.subject	Geography	en
dc.subject	Flight	en
dc.subject	Fuel	en
dc.title	Is there a link between aging and microbiome diversity in exceptional mammalian longevity?	en
dc.type	Article (peer-reviewed)	en

Is there a link between aging and microbiome diversity in exceptional mammalian longevity?

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