Is there a link between aging and microbiome diversity in exceptional mammalian longevity?

dc.contributor.authorHughes, Graham M.
dc.contributor.authorLeech, John
dc.contributor.authorPuechmaille, Sebastien J.
dc.contributor.authorLopez, Jose V.
dc.contributor.authorTeeling, Emma C.
dc.contributor.funderConseil Régional de Bretagne
dc.contributor.funderUniversity College Dublin
dc.contributor.funderEuropean Research Council
dc.date.accessioned2018-02-20T13:24:11Z
dc.date.available2018-02-20T13:24:11Z
dc.date.issued2018
dc.description.abstractA changing microbiome has been linked to biological aging in mice and humans, suggesting a possible role of gut flora in pathogenic aging phenotypes. Many bat species have exceptional longevity given their body size and some can live up to ten times longer than expected with little signs of aging. This study explores the anal microbiome of the exceptionally long-lived Myotis myotis bat, investigating bacterial composition in both adult and juvenile bats to determine if the microbiome changes with age in a wild, long-lived non-model organism, using non-lethal sampling. The anal microbiome was sequenced using metabarcoding in more than 50 individuals, finding no significant difference between the composition of juvenile and adult bats, suggesting that age-related microbial shifts previously observed in other mammals may not be present in Myotis myotis. Functional gene categories, inferred from metabarcoding data, expressed in the M. myotis microbiome were categorized identifying pathways involved in metabolism, DNA repair and oxidative phosphorylation. We highlight an abundance of 'Proteobacteria' relative to other mammals, with similar patterns compared to other bat microbiomes. Our results suggest that M. myotis may have a relatively stable, unchanging microbiome playing a role in their extended 'health spans' with the advancement of age, and suggest a potential link between microbiome and sustained, powered flight.en
dc.description.sponsorshipUniversity College Dublin (Seed funding grant); Conseil Régional de Bretagne (Contrat Nature (‘Etude de la dynamique des populations de grand murin (Myotis myotis) en Bretagne et Pays de Loire’)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide4174
dc.identifier.citationHughes, G. M., Leech, J., Puechmaille, S. J., Lopez, J. V. and Teeling, E. C. (2018) 'Is there a link between aging and microbiome diversity in exceptional mammalian longevity?', PeerJ, 6, e4174 (21pp). doi: 10.7717/peerj.4174en
dc.identifier.doi10.7717/peerj.4174
dc.identifier.endpage21
dc.identifier.issn2167-8359
dc.identifier.journaltitlePeerJen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5492
dc.identifier.volume6
dc.language.isoenen
dc.publisherPeerJ Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP2::ERC/311000/EU/Comparative genomics / ‘wildlife’ transcriptomics uncovers the mechanisms of halted ageing in mammals/AGELESS
dc.relation.urihttps://peerj.com/articles/4174/
dc.rights© 2018, Hughes et al. Distributed under Creative Commons CC-BY 4.0 https://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGut microbiotaen
dc.subjectHost phylogenyen
dc.subjectBatsen
dc.subjectConservationen
dc.subjectCommunitiesen
dc.subjectInformationen
dc.subjectEvolutionen
dc.subjectGeographyen
dc.subjectFlighten
dc.subjectFuelen
dc.titleIs there a link between aging and microbiome diversity in exceptional mammalian longevity?en
dc.typeArticle (peer-reviewed)en
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