Oxysterol-induced inflammation in human diseases: strategies for treatment with natural compounds and synthetic molecules
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Published Version
Date
2025-07-07
Authors
Brahmi, Fatiha
Mackrill, John J.
Ghzaiel, Imen
Rezig, Leila
Benkhalifa, Rym
Zarrouk, Amira
Jouanny, Pierre
Vejux, Anne
Lizard, Gérard
Journal Title
Journal ISSN
Volume Title
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Published Version
Abstract
Oxysterols can be derived from the diet, physiologically produced via specific enzymes, or are generated by autoxidation. These molecules have physiological properties and can also adversely affect vital organs. Indeed, some of them have pro-oxidant and pro-inflammatory activities and can lead to major pathologies. The present review focuses on oxysterols (7-ketocholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, and cholestane-3β, 5α, 6β-triol) involved either in cholesterol metabolism, age-related diseases (such as cardiovascular, neurodegenerative, and eye diseases, e.g., sarcopenia), and inflammatory diseases (especially Behcet’s disease and bowel and lung diseases (e.g., sarcoidosis, COVID-19)). Metabolic pathways associated with oxysterol-induced inflammation are discussed considering the cytokinic TLR4 pathway, non-cytokinic pathways, and the contribution of Ca2+ and K+ channels. Therapeutic approaches targeting oxysterol-induced inflammation either by natural or synthetic molecules are also presented.
Description
Keywords
Edible oils , Inflammatory diseases , Natural molecules , Nutrients , Oxysterols , Synthetic molecules
Citation
Brahmi, F., Mackrill, J. J., Ghzaiel, I., Rezig, L., Benkhalifa, R., Zarrouk, A., Jouanny, P., Vejux, A. and Lizard, G. (2025) 'Oxysterol-induced inflammation in human diseases: strategies for treatment with natural compounds and synthetic molecules', Molecules, 30(13), 2883 (47pp). https://doi.org/10.3390/molecules30132883