Oxysterol-induced inflammation in human diseases: strategies for treatment with natural compounds and synthetic molecules

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dc.contributor.authorBrahmi, Fatihaen
dc.contributor.authorMackrill, John J.en
dc.contributor.authorGhzaiel, Imenen
dc.contributor.authorRezig, Leilaen
dc.contributor.authorBenkhalifa, Rymen
dc.contributor.authorZarrouk, Amiraen
dc.contributor.authorJouanny, Pierreen
dc.contributor.authorVejux, Anneen
dc.contributor.authorLizard, Gérarden
dc.contributor.funderUniversité de Bourgogne Europeen
dc.contributor.funderUniversité de Béjaïaen
dc.contributor.funderUniversity College Corken
dc.date.accessioned2025-07-17T14:43:58Z
dc.date.available2025-07-17T14:43:58Z
dc.date.issued2025-07-07en
dc.description.abstractOxysterols can be derived from the diet, physiologically produced via specific enzymes, or are generated by autoxidation. These molecules have physiological properties and can also adversely affect vital organs. Indeed, some of them have pro-oxidant and pro-inflammatory activities and can lead to major pathologies. The present review focuses on oxysterols (7-ketocholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, and cholestane-3β, 5α, 6β-triol) involved either in cholesterol metabolism, age-related diseases (such as cardiovascular, neurodegenerative, and eye diseases, e.g., sarcopenia), and inflammatory diseases (especially Behcet’s disease and bowel and lung diseases (e.g., sarcoidosis, COVID-19)). Metabolic pathways associated with oxysterol-induced inflammation are discussed considering the cytokinic TLR4 pathway, non-cytokinic pathways, and the contribution of Ca2+ and K+ channels. Therapeutic approaches targeting oxysterol-induced inflammation either by natural or synthetic molecules are also presented.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2883en
dc.identifier.citationBrahmi, F., Mackrill, J. J., Ghzaiel, I., Rezig, L., Benkhalifa, R., Zarrouk, A., Jouanny, P., Vejux, A. and Lizard, G. (2025) 'Oxysterol-induced inflammation in human diseases: strategies for treatment with natural compounds and synthetic molecules', Molecules, 30(13), 2883 (47pp). https://doi.org/10.3390/molecules30132883en
dc.identifier.doi10.3390/molecules30132883en
dc.identifier.issn14203049en
dc.identifier.issued13
dc.identifier.journaltitleMoleculesen
dc.identifier.urihttps://hdl.handle.net/10468/17726
dc.identifier.volume30
dc.language.isoenen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.rights© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEdible oilsen
dc.subjectInflammatory diseasesen
dc.subjectNatural moleculesen
dc.subjectNutrientsen
dc.subjectOxysterolsen
dc.subjectSynthetic moleculesen
dc.titleOxysterol-induced inflammation in human diseases: strategies for treatment with natural compounds and synthetic moleculesen
dc.typeArticle (peer reviewed)en
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