dc.contributor.author	O'Farrell, Brian
dc.contributor.author	Benzie, John A. H.
dc.contributor.author	McGinnity, Philip
dc.contributor.author	de Eyto, Elvira
dc.contributor.author	Dillane, Eileen
dc.contributor.author	Coughlan, Jamie P.
dc.contributor.author	Cross, Thomas F.	en
dc.contributor.funder	Higher Education Authority	en
dc.contributor.funder	Irish Government	en
dc.contributor.funder	Science Foundation Ireland	en
dc.contributor.funder	Marine Institute	en
dc.date.accessioned	2016-02-17T11:46:18Z
dc.date.available	2016-02-17T11:46:18Z
dc.date.issued	2013
dc.description.abstract	We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population ( a sister species). High allelic diversity is observed and allelic divergence is much higher than that noted previously for cohabiting S. salar. Recombination was found to be important to population-level divergence. The alpha 1 and alpha 2 domains of UBA demonstrate ancient lineages but novel lineages are also identified at both domains in this work. We also find examples of recombination between UBA and the non-classical locus, ULA. Evidence for strong diversifying selection was found at a discrete suite of S. trutta UBA amino acid sites. The pattern was found to contrast with that found in re-analysed UBA data from an artificially stocked S. trutta population.	en
dc.description.sponsorship	Higher Education Authority (Programme for Research in Third-Level Institutions Cycle 3); Science Foundation Ireland (Microbial Phylogeography grant no. 05/FE1/B882); Marine Institute and Irish Government (Beaufort Marine Research Award: Fish population genetics. Irish Government National Development Plan (2007–2014));	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	e63035
dc.identifier.citation	O'Farrell B, Benzie JAH, McGinnity P, de Eyto E, Dillane E, Coughlan J, et al. (2013) Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain. PLoS ONE 8(5): e63035. doi:10.1371/journal.pone.0063035	en
dc.identifier.doi	10.1371/journal.pone.0063035
dc.identifier.issn	1932-6203
dc.identifier.issued	5	en
dc.identifier.journaltitle	PLOS ONE	en
dc.identifier.uri	https://hdl.handle.net/10468/2379
dc.identifier.volume	8	en
dc.language.iso	en	en
dc.publisher	Public Library of Science	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/05/FE1/B882/IE/Microbial Phylogeography/
dc.rights	© 2013 O'Farrell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.subject	Major histocompatibility complex	en
dc.subject	Peptide binding region	en
dc.subject	Rainbow trout	en
dc.subject	Oncorhynchus mykiss	en
dc.subject	Atlantic salmon	en
dc.subject	Natural selection	en
dc.subject	Balancing selection	en
dc.subject	Transspecies polymorphism	en
dc.subject	Convergent evolution	en
dc.subject	Parasite resistance	en
dc.title	Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain	en
dc.type	Article (peer-reviewed)	en

Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain

Files

Original bundle

Collections