Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat
| dc.contributor.author | McDonald, Fiona B. | |
| dc.contributor.author | Dempsey, Eugene M. | |
| dc.contributor.author | O'Halloran, Ken D. | |
| dc.contributor.funder | Health Research Board | en |
| dc.contributor.funder | University College Dublin | en |
| dc.date.accessioned | 2017-01-04T16:20:04Z | |
| dc.date.available | 2017-01-04T16:20:04Z | |
| dc.date.issued | 2016-07-12 | |
| dc.date.updated | 2017-01-04T16:14:27Z | |
| dc.description.abstract | Alterations to the supply of oxygen during early life presents a profound stressor to physiological systems with aberrant remodeling that is often long-lasting. Chronic intermittent hypoxia (CIH) is a feature of apnea of prematurity, chronic lung disease, and sleep apnea. CIH affects respiratory control but there is a dearth of information concerning the effects of CIH on respiratory muscles, including the diaphragm—the major pump muscle of breathing. We investigated the effects of exposure to gestational CIH (gCIH) and postnatal CIH (pCIH) on diaphragm muscle function in male and female rats. CIH consisted of exposure in environmental chambers to 90 s of hypoxia reaching 5% O2 at nadir, once every 5 min, 8 h a day. Exposure to gCIH started within 24 h of identification of a copulation plug and continued until day 20 of gestation; animals were studied on postnatal day 22 or 42. For pCIH, pups were born in normoxia and within 24 h of delivery were exposed with dams to CIH for 3 weeks; animals were studied on postnatal day 22 or 42. Sham groups were exposed to normoxia in parallel. Following gas exposures, diaphragm muscle contractile, and endurance properties were examined ex vivo. Neither gCIH nor pCIH exposure had effects on diaphragm muscle force-generating capacity or endurance in either sex. Similarly, early life exposure to CIH did not affect muscle tolerance of severe hypoxic stress determined ex vivo. The findings contrast with our recent observation of upper airway dilator muscle weakness following exposure to pCIH. Thus, the present study suggests a relative resilience to hypoxic stress in diaphragm muscle. Co-ordinated activity of thoracic pump and upper airway dilator muscles is required for optimal control of upper airway caliber. A mismatch in the force-generating capacity of the complementary muscle groups could have adverse consequences for the control of airway patency and respiratory homeostasis. | en |
| dc.description.sponsorship | University College Dublin (School of Medicine and Medical Science) | |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | McDonald, F. B., Dempsey, E. M. and O'Halloran, K. D. (2016) 'Effects of Gestational and Postnatal Exposure to Chronic Intermittent Hypoxia on Diaphragm Muscle Contractile Function in the Rat', Frontiers in Physiology, 7, 276 (10 pp). doi: 10.3389/fphys.2016.00276 | en |
| dc.identifier.doi | 10.3389/fphys.2016.00276 | |
| dc.identifier.endpage | 276-10 | en |
| dc.identifier.issn | 1664-042X | |
| dc.identifier.journaltitle | Frontiers in Physiology | en |
| dc.identifier.startpage | 276-1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/3426 | |
| dc.identifier.volume | 7 | en |
| dc.language.iso | en | en |
| dc.publisher | Frontiers Media | en |
| dc.rights | © 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Development | en |
| dc.subject | Early life stress | en |
| dc.subject | Perinatal | en |
| dc.subject | Respiratory muscle | en |
| dc.subject | Hypoxia | en |
| dc.title | Effects of gestational and postnatal exposure to chronic intermittent hypoxia on diaphragm muscle contractile function in the rat | en |
| dc.type | Article (peer-reviewed) | en |
