Microbiota regulates visceral pain in the mouse

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dc.contributor.authorLuczynski, Pauline
dc.contributor.authorTramullas, Monica
dc.contributor.authorViola, Maria F.
dc.contributor.authorShanahan, Fergus
dc.contributor.authorClarke, Gerard
dc.contributor.authorO'Mahony, Siobhain M.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderEuropean Commission
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2017-09-26T11:39:19Z
dc.date.available2017-09-26T11:39:19Z
dc.date.issued2017
dc.description.abstractThe perception of visceral pain is a complex process involving the spinal cord and higher order brain structures. Increasing evidence implicates the gut microbiota as a key regulator of brain and behavior, yet it remains to be determined if gut bacteria play a role in visceral sensitivity. We used germ-free mice (GF) to assess visceral sensitivity, spinal cord gene expression and pain-related brain structures. GF mice displayed visceral hypersensitivity accompanied by increases in Toll-like receptor and cytokine gene expression in the spinal cord, which were normalized by postnatal colonization with microbiota from conventionally colonized (CC). In GF mice, the volumes of the anterior cingulate cortex (ACC) and periaqueductal grey, areas involved in pain processing, were decreased and enlarged, respectively, and dendritic changes in the ACC were evident. These findings indicate that the gut microbiota is required for the normal visceral pain sensation.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide25887
dc.identifier.citationLuczynski, P., Tramullas, M., Viola, M., Shanahan, F., Clarke, G., O'Mahony, S., Dinan, T. G. and Cryan, J. F. (2017) 'Microbiota regulates visceral pain in the mouse', eLife, 6, e25887. (21pp). doi: 10.7554/eLife.25887en
dc.identifier.doi10.7554/eLife.25887
dc.identifier.issn2050-084X
dc.identifier.journaltitleeLifeen
dc.identifier.urihttps://hdl.handle.net/10468/4786
dc.identifier.volume6
dc.language.isoenen
dc.publishereLife Sciences Publications Ltden
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT
dc.relation.urihttps://elifesciences.org/articles/25887#
dc.rights© 2017, Luczynski et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIrritable bowel syndromeen
dc.subjectMedial prefrontal cortexen
dc.subjectGut brain axisen
dc.subjectColorectal distensionen
dc.subjectRectal distensionen
dc.subjectPathological painen
dc.subjectOpioid analgesiaen
dc.subjectNeuropathic painen
dc.subjectHost microbiotaen
dc.subjectStress responseen
dc.titleMicrobiota regulates visceral pain in the mouseen
dc.typeArticle (peer-reviewed)en
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