Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data
dc.contributor.author | Rejnmark, Lars | |
dc.contributor.author | Bislev, Lise Sofie | |
dc.contributor.author | Cashman, Kevin D. | |
dc.contributor.author | Eiriksdottir, Gudny | |
dc.contributor.author | Gaksch, Martin | |
dc.contributor.author | Gruebler, Martin | |
dc.contributor.author | Grimnes, Guri | |
dc.contributor.author | Gudnason, Vilmundur | |
dc.contributor.author | Lips, Paul | |
dc.contributor.author | Pilz, Stefan | |
dc.contributor.author | van Schoor, Natasja M. | |
dc.contributor.author | Kiely, Mairead E. | |
dc.contributor.author | Jorde, Rolf | |
dc.contributor.funder | Seventh Framework Programme | |
dc.date.accessioned | 2017-09-26T11:39:20Z | |
dc.date.available | 2017-09-26T11:39:20Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic quantitative review on characteristics of randomized clinical trials (RCTs) included in meta-analyses (MAs) on non-skeletal effects of vitamin D supplementation. Methods and findings We identified systematic reviews (SR) reporting summary data in terms of MAs of RCTs on selected non-skeletal outcomes. For each outcome, we summarized the results from available SRs and scrutinized included RCTs for a number of predefined characteristics. We identified 54 SRs including data from 210 RCTs. Most MAs as well as the individual RCTs reported null-findings on risk of cardiovascular diseases, type 2 diabetes, weight-loss, and malignant diseases. Beneficial effects of vitamin D supplementation was reported in 1 of 4 MAs on depression, 2 of 9 MAs on blood pressure, 3 of 7 MAs on respiratory tract infections, and 8 of 12 MAs on mortality. Most RCTs have primarily been performed to determine skeletal outcomes, whereas non-skeletal effects have been assessed as secondary outcomes. Only one-third of the RCTs had low level of 25OHD as a criterion for inclusion and a mean baseline 25OHD level below 50 nmol/L was only present in less than half of the analyses. Conclusions Published RCTs have mostly been performed in populations without low 25OHD levels. The fact that most MAs on results from RCTs did not show a beneficial effect does not disprove the hypothesis suggested by observational findings on adverse health outcomes of low 25OHD levels. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | e0180512 | |
dc.identifier.citation | Rejnmark, L., Bislev, L. S., Cashman, K. D., EirÃksdottir, G., Gaksch, M., Grübler, M., Grimnes, G., Gudnason, V., Lips, P., Pilz, S., van Schoor, N. M., Kiely, M. and Jorde, R. (2017) 'Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data', PLOS ONE, 12(7), e0180512 (39pp). doi: | en |
dc.identifier.doi | 10.1371/journal.pone.0180512 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.issued | 7 | |
dc.identifier.journaltitle | PLoS ONE | en |
dc.identifier.uri | https://hdl.handle.net/10468/4795 | |
dc.identifier.volume | 12 | |
dc.language.iso | en | en |
dc.publisher | Public Library of Science | en |
dc.relation.project | info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN | |
dc.relation.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180512 | |
dc.rights | © 2017, Rejnmark et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Randomized controlled trials | en |
dc.subject | Serum 25 hydroxyvitamin D | en |
dc.subject | Placebo controlled trial | en |
dc.subject | Nutrition examination survey | en |
dc.subject | 3Rd national health | en |
dc.subject | Respiratory tract infection | en |
dc.subject | Smooth muscle cells | en |
dc.subject | Impaired glucose tolerance | en |
dc.subject | Parathyroid hormone levels | en |
dc.subject | Controlled clinical trial | en |
dc.title | Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data | en |
dc.type | Article (peer-reviewed) | en |
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