Endocrine regulation of gut function - a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndrome

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dc.check.date2019-11-16
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorO'Malley, Dervla
dc.contributor.funderWellcome Trusten
dc.contributor.funderHealth Research Boarden
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderUniversity College Corken
dc.date.accessioned2019-01-21T11:33:32Z
dc.date.available2019-01-21T11:33:32Z
dc.date.issued2018-11-16
dc.date.updated2019-01-21T11:18:34Z
dc.description.abstractThe prevalent and debilitating functional bowel disorder, irritable bowel syndrome (IBS), is characterized by symptoms that include abdominal pain, bloating, diarrhoea and/or constipation. The heterogeneity of IBS underscores a complex multifactorial pathophysiology, which is not completely understood but involves dysfunction of the bi‐directional signalling axis between the brain and the gut. This axis incorporates efferent and afferent branches of the autonomic nervous system, circulating endocrine hormones and immune factors, local paracrine and neurocrine factors and microbial metabolites. L‐cells, which are electrically excitable biosensors embedded in the gastrointestinal epithelium, secrete glucagon‐like peptide‐1 (GLP‐1) in response to nutrients in the small intestine. However, they appear to function in a different manner more distally in the gastrointestinal tract, where they are activated by luminal factors including short‐chain fatty acids, bile acids and microbial metabolic products, all of which are altered in IBS patients. Glucagon‐like peptide‐1 can also interact with the hypothalamic–pituitary–adrenal stress axis and the immune system, both of which are activated in IBS. Given that a GLP‐1 mimetic has been found to alleviate acute pain symptoms in IBS patients, GLP‐1 might be important in the manifestation of IBS symptoms. This review assesses the current knowledge about the role of GLP‐1 in IBS pathophysiology and its potential role as a signal transducer in the microbiome–gut–brain signalling axis.en
dc.description.sponsorshipWellcome Trust‐Health Research Board‐Science Foundation Ireland (Seed Grant Number: WT108228MA); University College Cork (Translational Research Access Programme Grant Number: 2015)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Malley, D. (2018) 'Endocrine regulation of gut function - a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndrome', Experimental Physiology, 104(1), pp. 3-10. doi:10.1113/EP087443en
dc.identifier.doi10.1113/EP087443
dc.identifier.endpage10en
dc.identifier.issn0958-0670
dc.identifier.issn1469-445X
dc.identifier.issued1en
dc.identifier.journaltitleExperimental Physiologyen
dc.identifier.startpage3en
dc.identifier.urihttps://hdl.handle.net/10468/7326
dc.identifier.volume104en
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2018, the Author. Experimental Physiology © 2018, The Physiological Society. This is the peer reviewed version of the following article: O'Malley, D. (2018) 'Endocrine regulation of gut function - a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndrome', Experimental Physiology, 104(1), pp. 3-10. doi:10.1113/EP087443, which has been published in final form at https://doi.org/10.1113/EP087443. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectIrritable bowel syndromeen
dc.subjectGlucagon‐like peptide‐1en
dc.subjectL‐cellsen
dc.titleEndocrine regulation of gut function - a role for glucagon-like peptide-1 in the pathophysiology of irritable bowel syndromeen
dc.typeArticle (peer-reviewed)en
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