Herpetic tracheitis in association with rituximab therapy
Plant, Barry J.
Murphy, Desmond M.
A 58-year old lady under active follow-up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicular lesions on her vocal cords and trachea, confirmed as herpes simplex virus (HSV) on cytological analysis of brushings. She responded well to intravenous valacyclovir. Rituximab is increasingly utilised in the treatment of haematological and auto-immune disorders. This case highlights the potential of this drug to potentiate susceptibility to infection in an already immunocompromised individual.
Herpes simplex , Immunosuppression , Non-Hodgkin's lymphoma , Rituximab , Tracheitis
Thong, L., Plant, B. J., McCarthy, J. and Murphy, D. M. (2016) 'Herpetic tracheitis in association with rituximab therapy', Respirology Case Reports, 4(4), e00158. doi:10.1002/rcr2.158
© 2016 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.