The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation

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dc.contributor.authorEccles, Kevin S.
dc.contributor.authorDeasy, Rebecca E.
dc.contributor.authorFábián, László
dc.contributor.authorMaguire, Anita R.
dc.contributor.authorLawrence, Simon E.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Research Council for Science Engineering and Technologyen
dc.contributor.funderEli Lilly and Company, United Statesen
dc.date.accessioned2013-01-30T11:12:12Z
dc.date.available2013-01-30T11:12:12Z
dc.date.copyright2011-01
dc.date.issued2011-01
dc.date.updated2012-12-21T09:27:35Z
dc.description.abstractAbsolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of cocrystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Cocrystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.en
dc.description.sponsorshipScience Foundation Ireland (08/RFP/MTR1664); Science Foundation Ireland (07/SRC/B1158); Science Foundation Ireland (05/PICA/B802); Science Foundation Ireland (TIDA 09); Science Foundation Ireland (05/PICA/B802/EC07)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEccles, Kevin S., Deasy,Rebecca E., Fabian, Laszlo, Maguire, Anita R., Lawrence, Simon E. (2011) 'The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation'. Journal of Organic Chemistry, 76 (4):1159-1162. http://pubs.acs.org/doi/abs/10.1021/jo102148pen
dc.identifier.doi10.1021/jo102148p
dc.identifier.endpage1162en
dc.identifier.issn0022-3263
dc.identifier.issued4en
dc.identifier.journaltitleJournal of Organic Chemistryen
dc.identifier.startpage1159en
dc.identifier.urihttps://hdl.handle.net/10468/944
dc.identifier.volume76en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttp://pubs.acs.org/doi/abs/10.1021/jo102148p
dc.rights© 2011, American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jo102148pen
dc.subjectStereochemistryen
dc.subjectCo-crystallizationen
dc.subjectX-ray diffractionen
dc.subjectChiral HPLCen
dc.subject.lcshCrystallizationen
dc.titleThe use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formationen
dc.typeArticle (peer-reviewed)en
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