dc.contributor.author	Harris, Erin P.
dc.contributor.author	McGovern, Andrew J.
dc.contributor.author	Melo, Thieza G.
dc.contributor.author	Barron, Aaron
dc.contributor.author	Nolan, Yvonne M.
dc.contributor.author	O'Leary, Olive F
dc.contributor.funder	Health Research Board	en
dc.date.accessioned	2022-04-13T09:36:13Z
dc.date.available	2022-04-13T09:36:13Z
dc.date.issued	2022-03
dc.date.updated	2022-04-13T09:06:07Z
dc.description.abstract	Stress, particularly during childhood, is a major risk factor for the development of depression. Depression is twice as prevalent in women compared to men, which suggests that biological sex also contributes to depression susceptibility. However, the neurobiology underpinning sex differences in the long-term consequences of childhood stress remains unknown. Thus, the aim of this study was to determine whether stress applied during the prepubertal juvenile period (postnatal day 27–29) in rats induces sex-specific changes in anxiety-like behaviour, anhedonia, and antidepressant-like behaviour in adulthood in males and females. The impact of juvenile stress on two systems in the brain associated with these behaviours and that develop during the juvenile period, the mesocorticolimbic dopaminergic system and hippocampal neurogenesis, were also investigated. Juvenile stress altered escape-oriented behaviours in the forced swim test in both sexes, decreased latency to drink a palatable substance in a novel environment in the novelty-induced hypophagia test in both sexes, and decreased open field supported rearing behavior in females. These behavioural changes were accompanied by stress-induced increases in tyrosine hydroxylase immunoreactivity in the prefrontal cortex of both sexes, but not other regions of the mesocorticolimbic dopaminergic system. Juvenile stress did not impact anhedonia in adulthood as measured by the saccharin preference test and had no effect hippocampal neurogenesis across the longitudinal axis of the hippocampus. These results suggest that juvenile stress has long-lasting impacts on antidepressant-like and reward-seeking behaviour in adulthood and these changes may be due to alterations to catecholaminergic innervation of the medial prefrontal cortex.	en
dc.description.sponsorship	Health Research Board, Ireland (ILP-POR-2017-033)	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	113725	en
dc.identifier.citation	Harris, E. P., McGovern, A. J., Melo, T. G., Barron, A., Nolan, Y. M. and O'Leary, O. F. (2022) 'Juvenile stress exerts sex-independent effects on anxiety, antidepressant-like behaviours and dopaminergic innervation of the prelimbic cortex in adulthood and does not alter hippocampal neurogenesis, Behavioural Brain Research, 421, 113725 (14 pp). doi: 10.1016/j.bbr.2021.113725	en
dc.identifier.doi	10.1016/j.bbr.2021.113725	en
dc.identifier.endpage	14	en
dc.identifier.issn	1872-7549
dc.identifier.issued	421	en
dc.identifier.journaltitle	Behavioural Brain Research	en
dc.identifier.startpage	1	en
dc.identifier.uri	https://hdl.handle.net/10468/13078
dc.identifier.volume	421	en
dc.language.iso	en	en
dc.publisher	Elsevier	en
dc.relation.uri	https://www.sciencedirect.com/science/article/pii/S0166432821006136
dc.rights	© 2021 Elsevier B. V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	en
dc.subject	Stress	en
dc.subject	Sex differences	en
dc.subject	Depression	en
dc.subject	Neurogenesis	en
dc.subject	Dopamine	en
dc.subject	Prefrontal cortex	en
dc.title	Juvenile stress exerts sex-independent effects on anxiety, antidepressant-like behaviours and dopaminergic innervation of the prelimbic cortex in adulthood and does not alter hippocampal neurogenesis	en
dc.type	Article (peer-reviewed)	en

Juvenile stress exerts sex-independent effects on anxiety, antidepressant-like behaviours and dopaminergic innervation of the prelimbic cortex in adulthood and does not alter hippocampal neurogenesis

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