Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

dc.contributor.authorGheorghe, Cassandra Elise
dc.contributor.authorMartin, Jason A.
dc.contributor.authorVillalobos Manriquez, Francisca
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.authorClarke, Gerard
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderAir Force Office of Scientific Researchen
dc.date.accessioned2019-11-27T09:52:02Z
dc.date.available2019-11-27T09:52:02Z
dc.date.issued2019-10-14
dc.date.updated2019-11-27T09:43:11Z
dc.description.abstractThe gut-brain axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract, in which serotonin (5-HT) functions as a key neurotransmitter. Recent research has increasingly concentrated on tryptophan, the precursor to 5-HT and on the microbial regulation of tryptophan metabolism, with an emphasis on host-microbe control over kynurenine pathway metabolism and microbial-specific pathways that generate bioactive tryptophan metabolites. Here, we critically assess recent progress made towards a mechanistic understanding of the microbial regulation of tryptophan metabolism and microbiota-gut-brain axis homeostasis highlighting the role tryptophan metabolism plays in preclinical and clinical neuroscience and in the challenge to improve our understanding of how perturbed tryptophan metabolism contributes to stress-related psychiatric disorders.en
dc.description.sponsorshipHealth Research Board (Grant number ILP-POR-2017-013); Air Force Office of Scientific Research (Grant number FA9550-17-1-006)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGheorghe, C. E., Martin, J. A., Villalobos Manriquez, F., Dinan, T. G., Cryan, J. F. and Clarke, G. (2019) 'Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis', Current Opinion in Pharmacology, 48, pp. 137-145. doi: 10.1016/j.coph.2019.08.004en
dc.identifier.doi10.1016/j.coph.2019.08.004en
dc.identifier.eissn1471-4973
dc.identifier.endpage145en
dc.identifier.issn1471-4892
dc.identifier.journaltitleCurrent Opinion in Pharmacologyen
dc.identifier.startpage137en
dc.identifier.urihttps://hdl.handle.net/10468/9260
dc.identifier.volume48en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1471489218301279
dc.rights© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGut-brain axisen
dc.subjectCentral nervous systemen
dc.subjectGastrointestinal tracten
dc.subjectSerotoninen
dc.subject5-HTen
dc.subjectTryptophan metabolismen
dc.titleFocus on the essentials: tryptophan metabolism and the microbiome-gut-brain axisen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Tryptophan_Metabolism_Review_Accepted_Version_Cora_GC261119.pdf
Size:
819.14 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description: