Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

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dc.contributor.authorGheorghe, Cassandra Elise
dc.contributor.authorMartin, Jason A.
dc.contributor.authorVillalobos Manriquez, Francisca
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.authorClarke, Gerard
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderAir Force Office of Scientific Researchen
dc.date.accessioned2019-11-27T09:52:02Z
dc.date.available2019-11-27T09:52:02Z
dc.date.issued2019-10-14
dc.date.updated2019-11-27T09:43:11Z
dc.description.abstractThe gut-brain axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract, in which serotonin (5-HT) functions as a key neurotransmitter. Recent research has increasingly concentrated on tryptophan, the precursor to 5-HT and on the microbial regulation of tryptophan metabolism, with an emphasis on host-microbe control over kynurenine pathway metabolism and microbial-specific pathways that generate bioactive tryptophan metabolites. Here, we critically assess recent progress made towards a mechanistic understanding of the microbial regulation of tryptophan metabolism and microbiota-gut-brain axis homeostasis highlighting the role tryptophan metabolism plays in preclinical and clinical neuroscience and in the challenge to improve our understanding of how perturbed tryptophan metabolism contributes to stress-related psychiatric disorders.en
dc.description.sponsorshipHealth Research Board (Grant number ILP-POR-2017-013); Air Force Office of Scientific Research (Grant number FA9550-17-1-006)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGheorghe, C. E., Martin, J. A., Villalobos Manriquez, F., Dinan, T. G., Cryan, J. F. and Clarke, G. (2019) 'Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis', Current Opinion in Pharmacology, 48, pp. 137-145. doi: 10.1016/j.coph.2019.08.004en
dc.identifier.doi10.1016/j.coph.2019.08.004en
dc.identifier.eissn1471-4973
dc.identifier.endpage145en
dc.identifier.issn1471-4892
dc.identifier.journaltitleCurrent Opinion in Pharmacologyen
dc.identifier.startpage137en
dc.identifier.urihttps://hdl.handle.net/10468/9260
dc.identifier.volume48en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1471489218301279
dc.rights© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGut-brain axisen
dc.subjectCentral nervous systemen
dc.subjectGastrointestinal tracten
dc.subjectSerotoninen
dc.subject5-HTen
dc.subjectTryptophan metabolismen
dc.titleFocus on the essentials: tryptophan metabolism and the microbiome-gut-brain axisen
dc.typeArticle (peer-reviewed)en
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