Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome

dc.contributor.authorPatterson, Elaine
dc.contributor.authorRyan, Paul M.
dc.contributor.authorWiley, N.
dc.contributor.authorCarafa, Ilaria
dc.contributor.authorSherwin, Eoin
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorFranciosi, E.
dc.contributor.authorMandal, R.
dc.contributor.authorWishart, D. S.
dc.contributor.authorTuohy, K.
dc.contributor.authorRoss, R. Paul
dc.contributor.authorCryan, John F.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorStanton, Catherine
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderTeagascen
dc.contributor.funderUniversity of Albertaen
dc.contributor.funderIreland Canada University Foundationen
dc.date.accessioned2019-12-05T12:36:01Z
dc.date.available2019-12-05T12:36:01Z
dc.date.issued2019-11-08
dc.description.abstractMetabolic and neuroactive metabolite production represents one of the mechanisms through which the gut microbiota can impact health. One such metabolite, gamma-aminobutyric acid (GABA), can modulate glucose homeostasis and alter behavioural patterns in the host. We previously demonstrated that oral administration of GABA-producing Lactobacillus brevis DPC6108 has the potential to increase levels of circulating insulin in healthy rats. Therefore, the objective of this study was to assess the efficacy of endogenous microbial GABA production in improving metabolic and behavioural outcomes in a mouse model of metabolic dysfunction. Diet-induced obese and metabolically dysfunctional mice received one of two GABA-producing strains, L. brevis DPC6108 or L. brevis DSM32386, daily for 12 weeks. After 8 and 10 weeks of intervention, the behavioural and metabolic profiles of the mice were respectively assessed. Intervention with both L. brevis strains attenuated several abnormalities associated with metabolic dysfunction, causing a reduction in the accumulation of mesenteric adipose tissue, increased insulin secretion following glucose challenge, improved plasma cholesterol clearance and reduced despair-like behaviour and basal corticosterone production during the forced swim test. Taken together, this exploratory dataset indicates that intervention with GABA-producing lactobacilli has the potential to improve metabolic and depressive- like behavioural abnormalities associated with metabolic syndrome in mice.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid16323en
dc.identifier.citationPatterson, E., Ryan, P. M., Wiley, N., Carafa, I., Sherwin, E., Moloney, G., Franciosi, E., Mandal, R., Wishart, D. S., Tuohy, K., Ross, R. P., Cryan, J. F., Dinan, T. G. and Stanton, C. (2019) 'Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome', Scientific Reports, 9(1), 16323. (15pp.) doi: 10.1038/s41598-019-51781-xen
dc.identifier.doi10.1038/s41598-019-51781-xen
dc.identifier.eissn2045-2322
dc.identifier.endpage15en
dc.identifier.issued1en
dc.identifier.journaltitleScientific reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9345
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMetabolic syndromeen
dc.subjectMicrobiomeen
dc.subjectType 2 diabetesen
dc.titleGamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndromeen
dc.typeArticle (peer-reviewed)en
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