The microbiota-gut-brain axis

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dc.contributor.authorCryan, John F.
dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorSandhu, Kiran V.
dc.contributor.authorBastiaanssen, Thomaz F. S.
dc.contributor.authorBoehme, Marcus
dc.contributor.authorCodagnone, Martin G.
dc.contributor.authorCussotto, Sofia
dc.contributor.authorFulling, Christine
dc.contributor.authorGolubeva, Anna V.
dc.contributor.authorGuzzetta, Katherine E.
dc.contributor.authorJaggar, Minal
dc.contributor.authorLong-Smith, Caitriona M.
dc.contributor.authorLyte, Joshua M.
dc.contributor.authorMartin, Jason A.
dc.contributor.authorMolinero-Perez, Alicia
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorMorelli, Emanuela
dc.contributor.authorMorillas, Enrique
dc.contributor.authorO'Connor, Rory
dc.contributor.authorCruz-Pereira, Joana S.
dc.contributor.authorPeterson, Veronica L.
dc.contributor.authorRea, Kieran
dc.contributor.authorRitz, Nathaniel L.
dc.contributor.authorSherwin, Eoin
dc.contributor.authorSpichak, Simon
dc.contributor.authorTeichman, Emily M.
dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorVentura-Silva, Ana Paula
dc.contributor.authorWallace-Fitzsimons, Shauna E.
dc.contributor.authorHyland, Niall P.
dc.contributor.authorClarke, Gerard
dc.contributor.authorDinan, Timothy G.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderDepartment of Agriculture, Food and the Marine, Irelanden
dc.contributor.funderIrish Research Councilen
dc.contributor.funderHorizon 2020en
dc.date.accessioned2020-09-10T13:11:42Z
dc.date.available2020-09-10T13:11:42Z
dc.date.issued2019-08-28
dc.date.updated2020-09-10T12:48:25Z
dc.description.abstractThe importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson's disease, and Alzheimer's disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.en
dc.description.sponsorshipHealth Research Board of Ireland (Grants HRA_POR/2011/23 and HRA_POR/2012/32); Science Foundation Ireland (Joint Programming Initiative-a healthy diet for a healthy life (JPI-HDHL)-investigating Nutrition and Cognitive Function (NutriCog) by SFI Grant “A Menu for Brain Responses Opposing Stress-Induced Alternations in Cognition” (AMBROSIAC) 15/JP-HDHL/3270, as well as the Joint Programming Initiative “HEALTHMARK: Metabolic HEALTH through nutrition, microbiota and tryptophan bioMARKers,” 16/ERA-HDHL/3362 ); Irish Health Research Board (Grant ILP-POR-2017-013); Irish Research Council (Postgraduate Scholarships GOIPG/2019/3198, GOIPG/2018/2560)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., Guzzetta, K. E., Jaggar, M., Long-Smith, C. M., Lyte, J. M., Martin, J. A., Molinero-Perez, A., Moloney, G., Morelli, E., Morillas, E., O'Connor, R., Cruz-Pereira, J. S., Peterson, V. L., Rea, K., Ritz, N. L., Sherwin, E., Spichak, S., Teichman, E. M., Wouw, M. v. d., Ventura-Silva, A. P., Wallace-Fitzsimons, S. E., Hyland, N., Clarke, G. and Dinan, T. G. (2019) 'The Microbiota-Gut-Brain Axis', Physiological Reviews, 99(4), pp. 1877-2013. doi: 10.1152/physrev.00018.2018en
dc.identifier.doi10.1152/physrev.00018.2018en
dc.identifier.eissn1522-1210
dc.identifier.endpage2013en
dc.identifier.issn0031-9333
dc.identifier.issued4en
dc.identifier.journaltitlePhysiological reviewsen
dc.identifier.startpage1877en
dc.identifier.urihttps://hdl.handle.net/10468/10506
dc.identifier.volume99en
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUTen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/754535/EU/APC Postdoctoral EXcellence Programme/APEXen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMINDen
dc.relation.urihttps://journals.physiology.org/doi/full/10.1152/physrev.00018.2018
dc.rights© 2019 the American Physiological Societyen
dc.subjectBrain-guten
dc.subjectMicrobiomeen
dc.subjectNeurogastroenterologyen
dc.subjectSecond brainen
dc.subjectStressen
dc.titleThe microbiota-gut-brain axisen
dc.typeArticle (peer-reviewed)en
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