A paradigm shift in oxygen sensing with a twist in the tale!

dc.check.date2017-08-30
dc.check.infoAccess to this item is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorO'Halloran, Ken D.
dc.date.accessioned2017-03-21T09:33:32Z
dc.date.available2017-03-21T09:33:32Z
dc.date.issued2016-08-30
dc.date.updated2017-03-18T12:59:39Z
dc.description.abstractAMP-activated protein kinase (AMPK) is pivotal to metabolic homeostasis in eukaryotes, serving as a critical energy sensor. Increased AMPK activity during oxygen deprivation (hypoxia) protects against potentially catastrophic deficits in ATP supply. Whilst the nervous system circuitry for elaboration of the complex cardiorespiratory response to hypoxia has been understood in some detail for many decades, there is continued and considerable interest in the molecular machinery underpinning the mechanism(s) of oxygen sensing. In this issue of the Biochemical Journal, Evans et al. (2016) review their recent work, which points to a pivotal role for AMPK in the transduction of cellular hypoxic stress to integrated ventilatory behaviour, critical in the defence of whole-body oxygen homeostasis. Of great surprise, there is profound blunting of the hyperventilatory response to hypoxic stress in AMPK deficient mice, with resultant dysregulated breathing arising in spite of normal peripheral oxygen sensing and appropriate sensory input to the brain! Their pointedly provocative review challenges current dogma, and in doing so raises intriguing questions that probe fundamental aspects of our understanding of the mammalian ventilatory response to hypoxic stress. The engaging review by Evans et al. (2016) is an interesting read that is sure to encourage colourful debate.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Halloran, K. D. (2016) 'A paradigm shift in oxygen sensing with a twist in the tale!', Biochemical Journal, 473(17), pp.2687-2689; doi: 10.1042/BCJ20160500en
dc.identifier.doi10.1042/BCJ20160500
dc.identifier.endpage2689en
dc.identifier.issn0264-6021
dc.identifier.issued17en
dc.identifier.journaltitleBiochemical Journalen
dc.identifier.startpage2687en
dc.identifier.urihttps://hdl.handle.net/10468/3791
dc.identifier.volume473en
dc.language.isoenen
dc.publisherPortland Press Ltden
dc.rights© 2016, the Author. Published by Portland Press Limited on behalf of the Biochemical Society.en
dc.subjectActivated protein kinaseen
dc.subjectVentilatory responseen
dc.subjectHomeostasisen
dc.subjectMetabolismen
dc.subjectHypoxiaen
dc.subjectCarotid bodyen
dc.titleA paradigm shift in oxygen sensing with a twist in the tale!en
dc.typeArticle (peer-reviewed)en
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