Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome

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Date
2022
Authors
Mancabelli, Leonardo
Milani, Christian
Fontana, Federico
Lugli, Gabriele A.
Tarracchini, Chiara
Turroni, Francesca
van Sinderen, Douwe
Ventura, Marco
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Taylor and Francis Ltd.
Published Version
10.1080/20002297.2022.2051336
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Abstract
Background: The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.Aim: To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.Methods: In the current study, we performed an in-depth meta-analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.Results: The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.Conclusion: The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability.
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Keywords
Human respiratory tract , Oral microbiota , Pulmonary , Microbiome , Shotgun metagenomics , Sputum
Citation
Mancabelli, L., Milani, C., Fontana, F., Lugli, G.A., Tarracchini, C., Turroni, F., Van Sinderen, D. and Ventura, M. (2022) ‘Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome’, Journal of Oral Microbiology, 14(1), 2051336 (17pp). doi: 10.1080/20002297.2022.2051336
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https://hdl.handle.net/10468/15266
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APC Microbiome Ireland - Journal Articles
Microbiology - Journal Articles
Copyright
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.