Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome

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dc.contributor.authorMancabelli, Leonardoen
dc.contributor.authorMilani, Christianen
dc.contributor.authorFontana, Federicoen
dc.contributor.authorLugli, Gabriele A.en
dc.contributor.authorTarracchini, Chiaraen
dc.contributor.authorTurroni, Francescaen
dc.contributor.authorvan Sinderen, Douween
dc.contributor.authorVentura, Marcoen
dc.contributor.funderUniversità degli Studi di Parmaen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Commissionen
dc.contributor.funderMinistero dell'Università e della Ricercaen
dc.date.accessioned2023-11-28T12:46:15Z
dc.date.available2023-11-28T12:46:15Z
dc.date.issued2022en
dc.description.abstractBackground: The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.Aim: To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.Methods: In the current study, we performed an in-depth meta-analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.Results: The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.Conclusion: The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability.en
dc.description.sponsorshipMinistero dell'Università e della Ricerca, European Union (Programma Operativo Nazionale Ricerca eInnovazione” 2014-2020 (PON “R&I” 2014-2020) [project ARS01_00530])en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2051336en
dc.identifier.citationMancabelli, L., Milani, C., Fontana, F., Lugli, G.A., Tarracchini, C., Turroni, F., Van Sinderen, D. and Ventura, M. (2022) ‘Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome’, Journal of Oral Microbiology, 14(1), 2051336 (17pp). doi: 10.1080/20002297.2022.2051336en
dc.identifier.doi10.1080/20002297.2022.2051336en
dc.identifier.endpage17en
dc.identifier.issn2000-2297en
dc.identifier.issued1en
dc.identifier.journaltitleJournal of Oral Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15266
dc.identifier.volume14en
dc.language.isoenen
dc.publisherTaylor and Francis Ltd.en
dc.relation.ispartofJournal of Oral Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/COVID-19 Rapid Response Funding Programme::Phase 1/20/COV/0125/IE/COVIDBIOME; Microbiome-based biomarkers of COVID 19 disease outcomes/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectHuman respiratory tracten
dc.subjectOral microbiotaen
dc.subjectPulmonaryen
dc.subjectMicrobiomeen
dc.subjectShotgun metagenomicsen
dc.subjectSputumen
dc.titleMapping bacterial diversity and metabolic functionality of the human respiratory tract microbiomeen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue1en
oaire.citation.volume14en
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