Monocyte mobilisation, microbiota & mental illness

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dc.contributor.authorvan de Wouw, Marcel
dc.contributor.authorBoehme, Marcus
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-09-19T09:48:58Z
dc.date.available2019-09-19T09:48:58Z
dc.date.issued2019-07-19
dc.date.updated2019-09-19T09:39:28Z
dc.description.abstractThe gastrointestinal microbiome has emerged as a key player in regulating brain and behaviour. This has led to the strategy of targeting the gut microbiota to ameliorate disorders of the central nervous system. Understanding the underlying signalling pathways in which the microbiota impacts these disorders is crucial for the development of future therapeutics for improving CNS functionality. One of the major pathways through which the microbiota influences the brain is the immune system, where there is an increasing appreciation for the role of monocyte trafficking in regulating brain homeostasis. In this review, we will shed light on the role of monocyte trafficking as a relay of microbiota signals in conditions where the central nervous system is in disorder, such as stress, peripheral inflammation, ageing, traumatic brain injury, stroke, multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. We also cover how the gastrointestinal microbiota is implicated in these mental illnesses. In addition, we aim to discuss how the monocyte system can be modulated by the gut microbiota to mitigate disorders of the central nervous system, which will lead to novel microbiota-targeted strategies.en
dc.description.sponsorshipScience Foundation Ireland (SFI Grant AMBROSIAC (15/JP‐HDHL/3270))en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationvan de Wouw, M., Boehme, M., Dinan, T. G. and Cryan, J. F. (2019) 'Monocyte mobilisation, microbiota & mental illness', Brain, Behavior, and Immunity, 81, pp. 74-91. doi: 10.1016/j.bbi.2019.07.019en
dc.identifier.doi10.1016/j.bbi.2019.07.019en
dc.identifier.endpage91en
dc.identifier.issn0889-1591
dc.identifier.journaltitleBrain, Behavior, and Immunityen
dc.identifier.startpage74en
dc.identifier.urihttps://hdl.handle.net/10468/8570
dc.identifier.volume81en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0889159119306075
dc.rights© 2019, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 licence.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicrobiotaen
dc.subjectMonocytesen
dc.subjectBrainen
dc.subjectBehaviouren
dc.subjectImmune systemen
dc.subjectStressen
dc.subjectAgeingen
dc.subjectTraumatic brain injuryen
dc.subjectStrokeen
dc.subjectNeurodegenerationen
dc.titleMonocyte mobilisation, microbiota & mental illnessen
dc.typeArticle (peer-reviewed)en
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