Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland

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dc.contributor.authorMasukume, Gwinyai
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorBaker, Philip N.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorMorton, Susan M. B.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorKhashan, Ali S.
dc.contributor.funderHealth Research Boarden
dc.contributor.funderNational Children’s Research Centre, Irelanden
dc.contributor.funderFood Standards Agency, United Kingdomen
dc.date.accessioned2019-11-19T10:10:06Z
dc.date.available2019-11-19T10:10:06Z
dc.date.issued2019-03-15
dc.description.abstractObjectives: To investigate the association between caesarean section (CS) birth and body fat percentage (BF%), body mass index (BMI) and being overweight or obese in early childhood. Design: Prospective longitudinal cohort study. Setting: Babies After Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints cohort. Participants: Infants born to mothers recruited from the Screening for Pregnancy Endpoints study, Cork University Maternity Hospital between November 2007 and February 2011.Outcome measure: Overweight or obese defined according to the International Obesity Task Force criteria.Results: Of the 1305 infants, 362 (27.8%) were delivered by CS. On regression analysis, BF% at 2 months did not differ significantly by delivery mode. Infants born by CS had a higher mean BMI at 6 months compared with those born vaginally (adjusted mean difference=0.24; 95% CI 0.06 to 0.41, p value=0.009). At 2 years, no difference was seen across the exposure groups in the risk of being overweight or obese. At 5 years, the association between prelabour CS and the risk of overweight or obesity was not statistically significant (adjusted relative risk ratio, aRRR=1.37; 95% CI 0.69 to 2.69) and the association remained statistically nonsignificant when children who were macrosomic at birth were excluded from the model (aRRR=0.86; 95% CI 0.36 to 2.08).Conclusion: At 6 months of age, children born by CS had a significantly higher BMI but this did not persist into future childhood. There was no evidence to support an association between mode of delivery and long-term risk of obesity in the child.en
dc.description.sponsorshipTO7060; BASELINE; SCOPEen
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide025051en
dc.identifier.citationMasukume, G., McCarthy, F.P., Baker, P.N., Kenny, L.C., Morton, S.M., Murray, D.M., Hourihane, J.O.B. and Khashan, A.S., 2019. Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland. BMJ open, 9(3), (e025051). DOI:10.1136/bmjopen-2018-025051en
dc.identifier.doi10.1136/bmjopen-2018-025051en
dc.identifier.eissn2044-6055
dc.identifier.endpage8en
dc.identifier.issued3en
dc.identifier.journaltitleBMJ Openen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9040
dc.identifier.volume9en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://bmjopen.bmj.com/content/9/3/e025051
dc.rights© Author(s) (or their employer(s)) 2019.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectCaesarean section (CS)en
dc.subjectBirthen
dc.subjectBody fat percentageen
dc.subjectEarly childhooden
dc.subjectAssociationen
dc.titleAssociation between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Irelanden
dc.typeArticle (peer-reviewed)en
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