dc.contributor.author	Jeffery, Ian B.
dc.contributor.author	Lynch, Denise B.
dc.contributor.author	O'Toole, Paul W.
dc.contributor.funder	Department of Agriculture, Food and the Marine	en
dc.contributor.funder	Health Research Board	en
dc.contributor.funder	Science Foundation Ireland	en
dc.contributor.funder	General Mills Inc	en
dc.date.accessioned	2019-11-27T12:55:18Z
dc.date.available	2019-11-27T12:55:18Z
dc.date.issued	2015-06-19
dc.description.abstract	The composition and function of the human gut microbiota has been linked to health and disease. We previously identified correlations between habitual diet, microbiota composition gradients and health gradients in an unstratified cohort of 178 elderly subjects. To refine our understanding of diet–microbiota associations and differential taxon abundance, we adapted an iterative bi-clustering algorithm (iterative binary bclustering of gene sets (iBBiG)) and applied it to microbiota composition data from 732 faecal samples from 371 ELDERMET cohort subjects, including longitudinal samples. We thus identified distinctive microbiota configurations associated with ageing in both community and long-stay residential care elderly subjects. Mixed-taxa populations were identified that had clinically distinct associations. Microbiota temporal instability was observed in both community-dwelling and long-term care subjects, particularly in those with low initial microbiota diversity. However, the stability of the microbiota of subjects had little impact on the directional change of the microbiota as observed for long-stay subjects who display a gradual shift away from their initial microbiota. This was not observed in community-dwelling subjects. This directional change was associated with duration in long-stay. Changes in these bacterial populations represent the loss of the health-associated and youth-associated microbiota components and gain of an elderly associated microbiota. Interestingly, community-associated microbiota configurations were impacted more by the use of antibiotics than the microbiota of individuals in long-term care, as the community-associated microbiota showed more loss but also more recovery following antibiotic treatment. This improved definition of gut microbiota composition patterns in the elderly will better inform the design of dietary or antibiotic interventions targeting the gut microbiota.	en
dc.description.sponsorship	Health Research Board FHRI award to the ELDERMET project (07/FHRI/UCC/3)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Jeffery, I. B., Lynch, D. B. and O'Toole, P. W. (2016) 'Composition and temporal stability of the gut microbiota in older persons', The ISME Journal, 10(1), pp. 170-182. doi: 10.1038/ismej.2015.88	en
dc.identifier.doi	10.1038/ismej.2015.88	en
dc.identifier.eissn	1751-7370
dc.identifier.endpage	182	en
dc.identifier.issn	1751-7362
dc.identifier.journaltitle	ISME Journal	en
dc.identifier.startpage	170	en
dc.identifier.uri	https://hdl.handle.net/10468/9269
dc.identifier.volume	10	en
dc.language.iso	en	en
dc.publisher	Nature Research	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2128/IE/Development of Knowledge Base Necessary for Novel Diagnostic and Therapeutic Pipeline for the Early Identification and Treatment of Rheumatoid Arthritis/	en
dc.rights	© The Author(s) 2016. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	en
dc.subject	Microbial ecology	en
dc.subject	Public health	en
dc.subject	Temporal stability	en
dc.subject	Gut microbiota	en
dc.title	Composition and temporal stability of the gut microbiota in older persons	en
dc.type	Article (peer-reviewed)	en

Composition and temporal stability of the gut microbiota in older persons

Files

Original bundle

License bundle

Collections