Enduring behavioral effects induced by birth by caesarean section in the mouse

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dc.contributor.authorMorais, Livia H.
dc.contributor.authorGolubeva, Anna V.
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorMoya-Perez, Angela
dc.contributor.authorVentura-Silva, Ana Paula
dc.contributor.authorArboleya, Silvia
dc.contributor.authorBastiaanssen, Thomaz F. S.
dc.contributor.authorO'Sullivan, Orla
dc.contributor.authorRea, Kieran
dc.contributor.authorBorre, Yuliya E.
dc.contributor.authorScott, Karen A.
dc.contributor.authorPatterson, Elaine
dc.contributor.authorCherry, Paul
dc.contributor.authorStilling, Roman M.
dc.contributor.authorHoban, Alan E.
dc.contributor.authorEl Aidy, Sahar
dc.contributor.authorSequeira, Ana M.
dc.contributor.authorBeers, Sasja
dc.contributor.authorMoloney, Rachel D.
dc.contributor.authorRenes, Ingrid B.
dc.contributor.authorWang, Shugui
dc.contributor.authorKnol, Jan
dc.contributor.authorRoss, R. Paul
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorCotter, Paul D.
dc.contributor.authorStanton, Catherine
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderDepartment of Agriculture, Food and the Marine, Irelanden
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superioren
dc.date.accessioned2022-03-16T14:52:35Z
dc.date.available2022-03-16T14:52:35Z
dc.date.issued2020-01
dc.date.updated2022-03-16T12:20:51Z
dc.description.abstractBirth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. Moreover, alterations of the microbiome have been shown to affect neurodevelopmental trajectories. However, the long-term effects of C-section on neurobehavioral processes remain unknown. Here, we demonstrated that birth by C-section results in marked but transient changes in microbiome composition in the mouse, in particular, the abundance of Bifidobacterium spp. was depleted in early life. Mice born by C-section had enduring social, cognitive, and anxiety deficits in early life and adulthood. Interestingly, we found that these specific behavioral alterations induced by the mode of birth were also partially corrected by co-housing with vaginally born mice. Finally, we showed that supplementation from birth with a Bifidobacterium breve strain, or with a dietary prebiotic mixture that stimulates the growth of bifidobacteria, reverses selective behavioral alterations in C-section mice. Taken together, our data link the gut microbiota to behavioral alterations in C-section-born mice and suggest the possibility of developing adjunctive microbiota-targeted therapies that may help to avert long-term negative consequences on behavior associated with C-section birth mode.en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine, Ireland (TODDLERFOOD: Food Solutions for Replenishing Disrupted Microbiota in Toddlers (2014–2018)),(SMARTFOOD: Science Based “Intelligent”/Functional and Medical Foods for Optimum Brain Health, Targeting Depression and Cognition (2013–2017)); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (grant agreement number no. 11601-13-2)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMorais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Perez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O'Sullivan, O., Rea, K., Borre, Y. E., Scott, K. A., Patterson, E., Cherry, P., Stilling, R. M., Hoban, A. E., El Aidy, S., Sequeira, A. M., Beers, S., Moloney, R. D., Renes, I. B., Wang, S., Knol, J., Ross, R. P., O'Toole, P. W., Cotter, P. D., Stanton, C., Dinan, T. G. and Cryan, J. F. (2020) 'Enduring behavioral effects induced by birth by caesarean section in the mouse', Current Biology, 30 (19), pp. 3761-3774. doi: 10.1016/j.cub.2020.07.044en
dc.identifier.doi10.1016/j.cub.2020.07.044en
dc.identifier.endpage3774en
dc.identifier.issn0960-9822
dc.identifier.issued19en
dc.identifier.journaltitleCurrent Biologyen
dc.identifier.startpage3761en
dc.identifier.urihttps://hdl.handle.net/10468/12936
dc.identifier.volume30en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUTen
dc.rights© 2020 The Authors. Published by Elsevier Inc.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBehavioren
dc.subjectCaesarean sectionen
dc.subjectCo-housingen
dc.subjectGut-brain axisen
dc.subjectMicrobiotaen
dc.subjectMicrobiota gut-brain axisen
dc.subjectPrebioticsen
dc.subjectProbioticsen
dc.titleEnduring behavioral effects induced by birth by caesarean section in the mouseen
dc.typeArticle (peer-reviewed)en
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