Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol
| dc.contributor.author | Maher, Gillian M. | |
| dc.contributor.author | O'Keeffe, Gerard W. | |
| dc.contributor.author | Kenny, Louise C. | |
| dc.contributor.author | Kearney, Patricia M. | |
| dc.contributor.author | Dinan, Timothy G. | |
| dc.contributor.author | Khashan, Ali S. | |
| dc.contributor.funder | Science Foundation Ireland | |
| dc.contributor.funder | Health Research Board | |
| dc.date.accessioned | 2017-12-08T13:33:43Z | |
| dc.date.available | 2017-12-08T13:33:43Z | |
| dc.date.issued | 2017-10-01 | |
| dc.description.abstract | Introduction Hypertensive disorders of pregnancy (HDPs), that is chronic hypertension, gestational hypertension, pre-eclampsia (de novo or superimposed on chronic hypertension) and white coat hypertension, affect approximately 5%–15% of pregnancies. HDP exposure has been linked to an increased risk of autism spectrum disorder, attention deficit/hyperactivity disorder and other neurodevelopmental disorders in children. However, findings are inconsistent, and a clear consensus on the impact of HDPs on the risk of neurodevelopmental disorders is needed. Therefore, we aim to synthesise the published literature on the relationship between HDPs and the risk of neurodevelopmental disorders in the form of a systematic review and meta-analysis. Methods and analysis We will include cohort, case– control and cross-sectional studies in which diagnosis of an HDP was reported, and neurodevelopmental disorders were the outcome of interest based on a preprepared protocol. A systematic search of PubMed, CINAHL, Embase, PsycINFO and Web of Science will be conducted in accordance with a detailed search strategy. Two authors will independently review the titles and abstracts of all studies, perform data extraction using a standardised data collection form and assess study quality using a bias classification tool. Meta-analyses will be performed to calculate overall pooled estimates using the generic inverse variance method. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses. Ethics and dissemination This proposed systematic review and meta-analysis is based on published data, therefore, does not require ethics approval. Findings will be presented at scientific conferences and disseminated through publication in a peer-reviewed journal. Registration CRD42017068258. | en |
| dc.description.sponsorship | Health Research Board (SPHeRE (Structured Population and Health-services Research Education) | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.articleid | e018313 | |
| dc.identifier.citation | Maher, G. M., O'Keeffe, G. W., Kenny, L. C., Kearney, P. M., Dinan, T. G. and Khashan, A. S. (2017) 'Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol', BMJ Open, 7(10), e018313 (6pp). doi:10.1136/bmjopen-2017-018313 | en |
| dc.identifier.doi | 10.1136/bmjopen-2017-018313 | |
| dc.identifier.endpage | 6 | |
| dc.identifier.issn | 2044-6055 | |
| dc.identifier.issued | 10 | |
| dc.identifier.journaltitle | BMJ Open | en |
| dc.identifier.startpage | 1 | |
| dc.identifier.uri | https://hdl.handle.net/10468/5142 | |
| dc.identifier.volume | 7 | |
| dc.language.iso | en | en |
| dc.publisher | BMJ Publishing Group | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ | |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | |
| dc.relation.uri | http://bmjopen.bmj.com/content/7/10/e018313 | |
| dc.rights | © 2017, the Authors, unless otherwise stated in the text of the article. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | Hypertensive disorders of pregnancy | en |
| dc.subject | HDPs | en |
| dc.subject | Pregnancy | en |
| dc.subject | Neurodevelopmental disorders | en |
| dc.title | Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol | en |
| dc.type | Article (peer-reviewed) | en |