Neutrophil extracellular trapping role in cancer, metastases, and cancer-related thrombosis: A narrative review of the current evidence base

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dc.contributor.authorEfrimescu, Catalin I.
dc.contributor.authorBuggy, Padraig M.
dc.contributor.authorBuggy, Donal J.
dc.date.accessioned2021-09-01T08:50:14Z
dc.date.available2021-09-01T08:50:14Z
dc.date.issued2021-08-03
dc.description.abstractPurpose of Review: Neutrophil extracellular trap (NET) formation is a newly discovered, reactive oxygen species-dependent regulated process, whereby neutrophils degranulate and extrude genetic material, after engulfing various infectious or neoplastic antigens, culminating in a measurable serologic footprint. Recent research has highlighted the involvement of NETs in cancer and cancer-related pathologies. We review the role of NET formation in cancer biology, prognosis and potential therapeutic modulators. Recent Findings: Elevated NET levels are associated with cancer metastasis and may be modified by some anaesthetic-analgesic techniques during tumour resection surgery. It promotes tumour cell migration, angiogenesis and hypercoagulability. Although there are potential anti-NET formation therapeutics available, their role has not been formally assessed in cancer patients. Summary: Limited available evidence suggests an association between elevated NET expression and cancer metastasis, but its validity as a prognostic indicator for cancer-related outcomes is inconclusive. Further observational and interventional studies are warranted to comprehend the potential prognostic and therapeutic role of NETs in cancer.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid118en
dc.identifier.citationEfrimescu, C. I., Buggy, P. M. and Buggy, D. J. (2021) 'Neutrophil extracellular trapping role in cancer, metastases, and cancer-related thrombosis: A narrative review of the current evidence base', Current Oncology Reports, 23, 118 (12pp). doi: 10.1007/s11912-021-01103-0en
dc.identifier.doi10.1007/s11912-021-01103-0en
dc.identifier.eissn1534-6269
dc.identifier.endpage12en
dc.identifier.issn1523-3790
dc.identifier.journaltitleCurrent Oncology Reportsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11814
dc.identifier.volume23en
dc.language.isoenen
dc.publisherSpringer Nature Switzerland AGen
dc.rights© 2021, the Authors, under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. This is a post-peer-review, pre-copyedit version of an article published in Current Oncology Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11912-021-01103-0en
dc.subjectNeutrophil extracellular trappingen
dc.subjectNETosisen
dc.subjectNETsen
dc.subjectWhite blood cellsen
dc.subjectNeutrophilsen
dc.subjectCanceren
dc.subjectMetastasesen
dc.subjectThrombosisen
dc.titleNeutrophil extracellular trapping role in cancer, metastases, and cancer-related thrombosis: A narrative review of the current evidence baseen
dc.typeArticle (peer-reviewed)en
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