Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain

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dc.contributor.authorCarroll, Siobhan Y.
dc.contributor.authorO'Mahony, Siobhain M.
dc.contributor.authorGrenham, Susan
dc.contributor.authorCryan, John F.en
dc.contributor.authorHyland, Niall P.
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2016-02-17T11:44:41Z
dc.date.available2016-02-17T11:44:41Z
dc.date.issued2013
dc.description.abstractThe interface between psychiatry and stress-related gastrointestinal disorders (GI), such as irritable bowel syndrome (IBS), is well established, with anxiety and depression the most frequently occurring comorbid conditions. Moreover, stress-sensitive Wistar Kyoto (WKY) rats, which display anxiety-and depressive-like behaviors, exhibit GI disturbances akin to those observed in stress-related GI disorders. Additionally, there is mounting preclinical and clinical evidence implicating mast cells as significant contributors to the development of abdominal visceral pain in IBS. In this study we examined the effects of the rat connective tissue mast cell (CTMC) stabiliser, disodium cromoglycate (DSCG) on visceral hypersensitivity and colonic ion transport, and examined both colonic and peritoneal mast cells from stress-sensitive WKY rats. DSCG significantly decreased abdominal pain behaviors induced by colorectal distension in WKY animals independent of a reduction in colonic rat mast cell mediator release. We further demonstrated that mast cell-stimulated colonic ion transport was sensitive to inhibition by the mast cell stabiliser DSCG, an effect only observed in stress-sensitive rats. Moreover, CTMC-like mast cells were significantly increased in the colonic submucosa of WKY animals, and we observed a significant increase in the proportion of intermediate, or immature, peritoneal mast cells relative to control animals. Collectively our data further support a role for mast cells in the pathogenesis of stress-related GI disorders.en
dc.description.sponsorshipScience Foundation Ireland (SFI Grant No. 02/CE/B124; 07/CE/B1368)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidUNSP e84718
dc.identifier.citationCarroll SY, O’Mahony SM, Grenham S, Cryan JF, Hyland NP (2013) Disodium Cromoglycate Reverses Colonic Visceral Hypersensitivity and Influences Colonic Ion Transport in a Stress-Sensitive Rat Strain. PLoS ONE 8(12): e84718. doi:10.1371/journal.pone.0084718
dc.identifier.doi10.1371/journal.pone.0084718
dc.identifier.issn1932-6203
dc.identifier.issued12en
dc.identifier.journaltitlePLOS ONEen
dc.identifier.urihttps://hdl.handle.net/10468/2347
dc.identifier.volume8en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2015 Carroll et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectIrritable bowel syndromeen
dc.subjectPeritoneal mast cellsen
dc.subjectNeonatal maternal deprivationen
dc.subjectInduced histamine releaseen
dc.subjectConnective tissue typeen
dc.subjectLong-term alterationsen
dc.subjectSodium cromoglycateen
dc.subjectAntiallergic compoundsen
dc.subjectRestraint stressen
dc.subjectIn vitroen
dc.titleDisodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strainen
dc.typeArticle (peer-reviewed)en
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